Literature DB >> 26921697

Lysosomes in cancer-living on the edge (of the cell).

Saara Hämälistö1, Marja Jäättelä2.   

Abstract

The lysosomes have definitely polished their status inside the cell. Being discovered as the last resort of discarded cellular biomass, the steady rising of this versatile signaling organelle is currently ongoing. This review discusses the recent data on the unconventional functions of lysosomes, focusing mainly on the less studied lysosomes residing in the cellular periphery. We emphasize our discussion on the emerging paths the lysosomes have taken in promoting cancer progression to metastatic disease. Finally, we address how the altered cancerous lysosomes in metastatic cancers may be specifically targeted and what are the pending questions awaiting for elucidation.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 26921697      PMCID： PMC7611282          DOI： 10.1016/j.ceb.2016.02.009

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  69 in total

1.  Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease.

Authors:  Christine Erie; Matthew Sacino; Lauren Houle; Michael L Lu; Jianning Wei
Journal:  Eur J Neurosci       Date:  2015-06-19       Impact factor: 3.386

2.  Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

Authors:  Shuyu Wang; Zhi-Yang Tsun; Rachel L Wolfson; Kuang Shen; Gregory A Wyant; Molly E Plovanich; Elizabeth D Yuan; Tony D Jones; Lynne Chantranupong; William Comb; Tim Wang; Liron Bar-Peled; Roberto Zoncu; Christoph Straub; Choah Kim; Jiwon Park; Bernardo L Sabatini; David M Sabatini
Journal:  Science       Date:  2015-01-07       Impact factor: 47.728

3.  ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.

Authors:  Bo Rafn; Christian Friberg Nielsen; Sofie Hagel Andersen; Piotr Szyniarowski; Elisabeth Corcelle-Termeau; Erkka Valo; Nicole Fehrenbacher; Charlotta Johanne Olsen; Mads Daugaard; Christina Egebjerg; Trine Bøttzauw; Pekka Kohonen; Jesper Nylandsted; Sampsa Hautaniemi; José Moreira; Marja Jäättelä; Tuula Kallunki
Journal:  Mol Cell       Date:  2012-03-30       Impact factor: 17.970

4.  Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis.

Authors:  B Tong; B Wan; Z Wei; T Wang; P Zhao; Y Dou; Z Lv; Y Xia; Y Dai
Journal:  Clin Exp Immunol       Date:  2014-09       Impact factor: 4.330

5.  Endocytic trafficking of laminin is controlled by dystroglycan and is disrupted in cancers.

Authors:  Dmitri Leonoudakis; Ge Huang; Armin Akhavan; Jimmie E Fata; Manisha Singh; Joe W Gray; John L Muschler
Journal:  J Cell Sci       Date:  2014-09-12       Impact factor: 5.285

Review 6.  Recent Insights into the Structure, Regulation, and Function of the V-ATPases.

Authors:  Kristina Cotter; Laura Stransky; Christina McGuire; Michael Forgac
Journal:  Trends Biochem Sci       Date:  2015-10       Impact factor: 13.807

7.  Actin cytoskeleton controls movement of intracellular organelles in pancreatic duct epithelial cells.

Authors:  Seung-Ryoung Jung; Jong Bae Seo; Donghwan Shim; Bertil Hille; Duk-Su Koh
Journal:  Cell Calcium       Date:  2012-05-10       Impact factor: 6.817

8.  Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.

Authors:  Carla M P Cardoso; Line Groth-Pedersen; Maria Høyer-Hansen; Thomas Kirkegaard; Elizabeth Corcelle; Jens S Andersen; Marja Jäättelä; Jesper Nylandsted
Journal:  PLoS One       Date:  2009-02-10       Impact factor: 3.240

Review 9.  The role of the cytoskeleton and molecular motors in endosomal dynamics.

Authors:  Elizabeth Granger; Gavin McNee; Victoria Allan; Philip Woodman
Journal:  Semin Cell Dev Biol       Date:  2014-04-13       Impact factor: 7.727

10.  Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization.

Authors:  Timothy J Sargeant; Bethan Lloyd-Lewis; Henrike K Resemann; Antonio Ramos-Montoya; Jeremy Skepper; Christine J Watson
Journal:  Nat Cell Biol       Date:  2014-10-05       Impact factor: 28.824
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  47 in total

1.  Lysosome Positioning Influences mTORC2 and AKT Signaling.

Authors:  Rui Jia; Juan S Bonifacino
Journal:  Mol Cell       Date:  2019-05-23       Impact factor: 17.970

2.  Lysosome Membrane Permeabilization and Disruption of the Molecular Target of Rapamycin (mTOR)-Lysosome Interaction Are Associated with the Inhibition of Lung Cancer Cell Proliferation by a Chloroquinoline Analog.

Authors:  Juan Sironi; Evelyn Aranda; Lars Ulrik Nordstrøm; Edward L Schwartz
Journal:  Mol Pharmacol       Date:  2018-11-08       Impact factor: 4.436

Review 3.  Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.

Authors:  Maria Letizia Ciavatta; Florence Lefranc; Marianna Carbone; Ernesto Mollo; Margherita Gavagnin; Tania Betancourt; Ramesh Dasari; Alexander Kornienko; Robert Kiss
Journal:  Med Res Rev       Date:  2016-12-07       Impact factor: 12.944

Review 4.  The lysosome as a cellular centre for signalling, metabolism and quality control.

Authors:  Rosalie E Lawrence; Roberto Zoncu
Journal:  Nat Cell Biol       Date:  2019-01-02       Impact factor: 28.824

5.  GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma.

Authors:  Sonia Brun; Firas Bassissi; Cindy Serdjebi; Marie Novello; Jennifer Tracz; François Autelitano; Marie Guillemot; Philippe Fabre; Jérôme Courcambeck; Christelle Ansaldi; Eric Raymond; Philipe Halfon
Journal:  Invest New Drugs       Date:  2019-02-19       Impact factor: 3.850

6.  Metastatic cells are preferentially vulnerable to lysosomal inhibition.

Authors:  Michael J Morgan; Brent E Fitzwalter; Charles R Owens; Rani K Powers; Joseph L Sottnik; Graciela Gamez; James C Costello; Dan Theodorescu; Andrew Thorburn
Journal:  Proc Natl Acad Sci U S A       Date:  2018-08-20       Impact factor: 11.205

7.  'Patchiness' and basic cancer research: unravelling the proteases.

Authors:  Surinder M Soond; Maria V Kozhevnikova; Andrey A Zamyatnin
Journal:  Cell Cycle       Date:  2019-06-24       Impact factor: 4.534

Review 8.  Lysosomal Biology in Cancer.

Authors:  Colin Fennelly; Ravi K Amaravadi
Journal:  Methods Mol Biol       Date:  2017

9.  Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion.

Authors:  Ditte Marie Brix; Siri Amanda Tvingsholm; Malene Bredahl Hansen; Knut Bundgaard Clemmensen; Tiina Ohman; Valentina Siino; Matteo Lambrughi; Klaus Hansen; Pietri Puustinen; Irina Gromova; Peter James; Elena Papaleo; Markku Varjosalo; José Moreira; Marja Jäättelä; Tuula Kallunki
Journal:  Oncogene       Date:  2019-01-08       Impact factor: 9.867

10.  DNAJA1 Dysregulates Metabolism Promoting an Antiapoptotic Phenotype in Pancreatic Ductal Adenocarcinoma.

Authors:  Heidi E Roth; Fatema Bhinderwala; Rodrigo Franco; You Zhou; Robert Powers
Journal:  J Proteome Res       Date:  2021-07-15       Impact factor: 4.466
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