Manuela Vaneckova1, Sergey Zakharov2, Jiri Klempir3, Evzen Ruzicka3, Ondrej Bezdicek3, Hana Brozova3, Pavel Diblik4, Michal Miovsky5, Jaroslav Alois Hubacek6, Pavel Urban2, Petr Ridzon2, Daniela Pelclova2, Andrea Burgetova1, Martin Masek1, Katerina Kotikova2, Kamila Peterova3, Irena Liskova3, Lidmila Hamplova7, Zdenek Seidl1. 1. MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. 2. Department of Occupational Medicine of the First Faculty of Medicine and General University Hospital, Charles University Prague, Czech Republic. 3. Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic. 4. Department of Ophthalmology, Charles University in Prague, First Faculty of Medicine and General University Hospital, Czech Republic. 5. Department of Addictology, Charles University in Prague, First Faculty of Medicine and General University Hospital, Czech Republic. 6. Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. 7. The College of Nursing, o.p. s, Duskova, Prague, Czech Republic.
Abstract
OBJECTIVES: Our goal is to demonstrate the variability of imaging findings, primarily in the MRI, in 46 patients who survived acute methanol poisoning. This cohort of patients is the largest such sample group examined by MRI. METHODS: Patients were examined by means of imaging methods (42 patients by MRI and 4 by CT). All had an identical protocol of MR examination (T2WI, FLAIR, T1WI with or without application of contrast medium and T2WI/FFE, DWI in the transversal plane of the scan, and with focus on the optic nerves in the coronal plane of the scan in T2WI-SPIR). RESULTS: Imaging methods revealed a positive finding associated with methanol intoxication in 21 patients (46%). These consisted of symmetrical lesions in the putamen--13 patients (28%), haemorrhage--13 cases (28%), deposits in white matter with localization primarily subcortically--4 cases (9%), lesions in the region of the globus pallidus--7 cases (15%) (in 6 cases without combination with the lesions in the putamen), lesions in the brainstem afflicted 6 patients (13%), and lesion in the cerebellum was found in one case. A pathological finding was found only in the patients examined by MRI. CONCLUSION: Almost half of the patients who survived acute methanol poisoning had pathological findings by MRI. The most common finding concerned an affliction of the putamen, which is a predilection area. An interesting finding was the relatively frequent occurrence of selective lesion of the globus pallidus, which is more usually associated with other types of intoxication.
OBJECTIVES: Our goal is to demonstrate the variability of imaging findings, primarily in the MRI, in 46 patients who survived acute methanolpoisoning. This cohort of patients is the largest such sample group examined by MRI. METHODS:Patients were examined by means of imaging methods (42 patients by MRI and 4 by CT). All had an identical protocol of MR examination (T2WI, FLAIR, T1WI with or without application of contrast medium and T2WI/FFE, DWI in the transversal plane of the scan, and with focus on the optic nerves in the coronal plane of the scan in T2WI-SPIR). RESULTS: Imaging methods revealed a positive finding associated with methanol intoxication in 21 patients (46%). These consisted of symmetrical lesions in the putamen--13 patients (28%), haemorrhage--13 cases (28%), deposits in white matter with localization primarily subcortically--4 cases (9%), lesions in the region of the globus pallidus--7 cases (15%) (in 6 cases without combination with the lesions in the putamen), lesions in the brainstem afflicted 6 patients (13%), and lesion in the cerebellum was found in one case. A pathological finding was found only in the patients examined by MRI. CONCLUSION: Almost half of the patients who survived acute methanolpoisoning had pathological findings by MRI. The most common finding concerned an affliction of the putamen, which is a predilection area. An interesting finding was the relatively frequent occurrence of selective lesion of the globus pallidus, which is more usually associated with other types of intoxication.
Authors: Miroslav Barták; Vladimír Rogalewicz; Jaroslav Doubek; Jaroslav Šejvl; Benjamin Petruželka; Sergey Zakharov; Michal Miovský Journal: BMJ Open Date: 2021-05-19 Impact factor: 2.692
Authors: Sergey Zakharov; Jan Rulisek; Olga Nurieva; Katerina Kotikova; Tomas Navratil; Martin Komarc; Daniela Pelclova; Knut Erik Hovda Journal: Ann Intensive Care Date: 2017-07-20 Impact factor: 6.925