Abbas Monzavi1, Zahra Chinipardaz1, Mahvash Mousavi2, Reza Fekrazad3, Neda Moslemi2, Adriano Azaripour4, Omid Bagherpasand5, Nasim Chiniforush6. 1. Laser Research Center of Dentistry, Dental Research Institute, Tehran University of Medial Sciences, Tehran, Iran. 2. Department of Periodontics, School of Dentistry, Tehran University of Medial Sciences, Tehran, Iran. 3. Laser Research Center in Medical Sciences (LRCMS), AJA University of Medical Sciences, Tehran, Iran. 4. Department of Operative Dentistry and Periodontology, University Medical Center of the Johannes Gutenberg-University Mainz, Germany. 5. Dentist, Private Practice, Tehran, Iran. 6. Laser Research Center of Dentistry, Dental Research Institute, Tehran University of Medial Sciences, Tehran, Iran. Electronic address: n-chiniforush@farabi.tums.ac.ir.
Abstract
INTRODUCTION: Clinical studies have shown the usefulness of antimicrobial photodynamic therapy (aPDT) as an adjunctive in periodontal therapy. These studies did not utilize indocyanine green (ICG) as a recently introduced photosensitizer. The aim of this study was to perform a full-mouth double-blind randomized controlled clinical study to test the efficacy of adjunctiveaPDT with ICG compared with scaling and root planing (SRP) alone in chronic periodontitis treatment. MATERIALS AND METHODS:Fifty patients were selected for this study. All patients received SRP. Then, each patient was randomly assigned to either the test group (aPDT+SRP) or the control group (SRP). aPDT was performed with a diode laser (wavelength: 810nm, power: 200mW) and ICG as photosensitizer. The adjunctive procedure was repeated after 7, 17 and 27 days. The clinical parameters including bleeding on probing (BOP), clinical attachment loss (CAL), plaque index (PI), probing pocket depth (PPD), full mouth plaque score (FMPS) and full mouth bleeding score (FMBS) were measured at baseline and after 1 and 3 months. RESULTS: There were no significant differences between two groups at baseline. BOP, PPD and FMBS showed significant improvements in the test group (P≤0.001). In terms of PI, FMPS and CAL, no significant differences were observed between both groups (P≥0.05). CONCLUSION:aPDT as an adjunctive approach yielded complete resolution of inflammation and significant reduction in periodontal pocket depth. However, aPDT had no additional advantages in clinical attachment gain and plaque score.
RCT Entities:
INTRODUCTION: Clinical studies have shown the usefulness of antimicrobial photodynamic therapy (aPDT) as an adjunctive in periodontal therapy. These studies did not utilize indocyanine green (ICG) as a recently introduced photosensitizer. The aim of this study was to perform a full-mouth double-blind randomized controlled clinical study to test the efficacy of adjunctive aPDT with ICG compared with scaling and root planing (SRP) alone in chronic periodontitis treatment. MATERIALS AND METHODS: Fifty patients were selected for this study. All patients received SRP. Then, each patient was randomly assigned to either the test group (aPDT+SRP) or the control group (SRP). aPDT was performed with a diode laser (wavelength: 810nm, power: 200mW) and ICG as photosensitizer. The adjunctive procedure was repeated after 7, 17 and 27 days. The clinical parameters including bleeding on probing (BOP), clinical attachment loss (CAL), plaque index (PI), probing pocket depth (PPD), full mouth plaque score (FMPS) and full mouth bleeding score (FMBS) were measured at baseline and after 1 and 3 months. RESULTS: There were no significant differences between two groups at baseline. BOP, PPD and FMBS showed significant improvements in the test group (P≤0.001). In terms of PI, FMPS and CAL, no significant differences were observed between both groups (P≥0.05). CONCLUSION:aPDT as an adjunctive approach yielded complete resolution of inflammation and significant reduction in periodontal pocket depth. However, aPDT had no additional advantages in clinical attachment gain and plaque score.
Authors: Sakari Nikinmaa; Niina Moilanen; Timo Sorsa; Juha Rantala; Heikki Alapulli; Anja Kotiranta; Petri Auvinen; Esko Kankuri; Jukka H Meurman; Tommi Pätilä Journal: Dent J (Basel) Date: 2021-05-03