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Literature DB >> 2692124

Cellular basis and oncogene expression of rheumatoid joint destruction.

Abstract

A new animal model for human rheumatoid arthritis is described, and the unsolved questions regarding the mechanism of primary joint destruction are discussed. Following an analysis of the types of cells and antibodies found in joints affected by rheumatoid arthritis, it is concluded that both expression of oncogenes and the presence of retroviral sequences detectable by monoclonal antibodies to HTLV I p19 and p24 sequences are associated with early abnormal proliferation of apparently transformed cells at the site of initial cartilage and/or bone destruction.

Entities: Disease Species

Mesh：

Substances：

Year: 1989 PMID： 2692124 DOI： 10.1007/bf00271866

Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631

45 in total

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Authors: S Gay; F X O'Sullivan; R E Gay; W J Koopman
Journal: Clin Immunol Immunopathol Date: 1987-10

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Authors: S Gay; J D Fine
Journal: Methods Enzymol Date: 1987 Impact factor: 1.600

3. Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.

Authors: L J Joseph; L C Chang; D Stamenkovich; V P Sukhatme
Journal: J Clin Invest Date: 1988-05 Impact factor: 14.808

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Journal: Int Rev Exp Pathol Date: 1984

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Journal: Cell Tissue Res Date: 1978-12-28 Impact factor: 5.249

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Authors: A Tanaka; F X O'Sullivan; W J Koopman; S Gay
Journal: J Rheumatol Date: 1988-01 Impact factor: 4.666

Review 7. Pathogenesis of rheumatoid arthritis.

Authors: E D Harris
Journal: Clin Orthop Relat Res Date: 1984 Jan-Feb Impact factor: 4.176

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Journal: Scand J Immunol Date: 1981-10 Impact factor: 3.487

9. Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon.

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Journal: J Exp Med Date: 1983-04-01 Impact factor: 14.307

10. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

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Journal: J Exp Med Date: 1978-11-01 Impact factor: 14.307

13 in total

1. Comparison of modern marker proteins in serum and synovial fluid in patients with advanced osteoarthrosis and rheumatoid arthritis.

Authors: S Andereya; N Streich; B Schmidt-Rohlfing; T Mumme; R Müller-Rath; U Schneider
Journal: Rheumatol Int Date: 2005-07-06 Impact factor: 2.631

2. [Imaging in the early diagnosis of changes in the hand of patients suffering from rheumatoid arthritis. Is ultrasound a true alternative for low-field magnetic resonance scanning, 3-phase bone scintigraphy and conventional x-rays?].

Authors: S Höpfner; C Krolak; M Treitl; C Becker-Gaab; H Kellner; R Tiling
Journal: Z Rheumatol Date: 2007-02 Impact factor: 1.372

Review 3. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?

Authors: S Gay; R E Gay; W J Koopman
Journal: Ann Rheum Dis Date: 1993-03 Impact factor: 19.103

4. Basement membrane proteins in synovial membrane: distribution in rheumatoid arthritis and synthesis by fibroblast-like cells.

Authors: M Schneider; B Voss; J Rauterberg; M Menke; T Pauly; R K Miehlke; J Friemann; U Gerlach
Journal: Clin Rheumatol Date: 1994-03 Impact factor: 2.980

5. Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts.

Authors: Elena Neumann; Birgit Riepl; Anette Knedla; Stephanie Lefèvre; Ingo H Tarner; Joachim Grifka; Jurgen Steinmeyer; Jurgen Schölmerich; Steffen Gay; Ulf Müller-Ladner
Journal: Arthritis Res Ther Date: 2010-05-12 Impact factor: 5.156

Review 6. Retroviruses and autoimmune rheumatic diseases.

Authors: J R Kalden; S Gay
Journal: Clin Exp Immunol Date: 1994-10 Impact factor: 4.330

7. Constitutive c-fos expression in osteoblastic MC3T3-E1 cells stimulates osteoclast maturation and osteoclastic bone resorption.

Authors: Y Kuroki; S Shiozawa; T Sugimoto; M Kanatani; H Kaji; A Miyachi; K Chihara
Journal: Clin Exp Immunol Date: 1994-03 Impact factor: 4.330

8. Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts.

Authors: A Trabandt; W K Aicher; R E Gay; V P Sukhatme; H G Fassbender; S Gay
Journal: Rheumatol Int Date: 1992 Impact factor: 2.631

9. Scanning electron microscopic evaluation of the arthritis in MRL/lpr mice.

Authors: F X O'Sullivan; W J Koopman; S Gay
Journal: Rheumatol Int Date: 1992 Impact factor: 2.631

10. Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases.

Authors: Kris A Reedquist; Paul P Tak
Journal: Open Rheumatol J Date: 2012-09-07