OBJECTIVE: Corpus callosum (CC) abnormalities are frequently reported in patients with refractory mesial temporal lobe epilepsy (rMTLE). However, whether CC structural alterations are related to the epileptic syndrome itself or to refractoriness is still unknown. Thus, we aimed to compare patterns of CC change in patients with rMTLE and benign MTLE (bMTLE), the latter of which represents a useful resource to better disentangle factors that contribute to refractoriness. METHODS: The study group included 79 patients with bMTLE (mean age 43.2 ± 14. 8 years), 61 with rMTLE (mean age 45.2 ± 12.4 years) and 134 healthy volunteers. Structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were performed to measure thickness, mean diffusivity (MD), and fractional anisotropy (FA) over 50 regions of interest along the cross-sectional CC profile. Statistical analysis comprised analysis of variance (ANOVA) followed by post hoc Tukey's Honest Significant Difference test. RESULTS: We found that all imaging metrics of the CC splenium were altered in rMTLE patients compared to bMTLE and controls. We also found significantly reduced thickness and FA of the anterior CC in rMTLE compared to controls and that FA was reduced only in rMTLE compared to bMTLE. Patients with bMTLE did not differ from controls. Differences between disease subgroups were found in the midbody composed of sensorimotor fibers. SIGNIFICANCE: We found altered multimodal imaging metrics of the CC in rMTLE but not in bMTLE. These findings were independent of the radiologic presence of hippocampal sclerosis, suggesting that differences in the distribution of such alterations might be related to refractoriness. Wiley Periodicals, Inc.
OBJECTIVE: Corpus callosum (CC) abnormalities are frequently reported in patients with refractory mesial temporal lobe epilepsy (rMTLE). However, whether CC structural alterations are related to the epileptic syndrome itself or to refractoriness is still unknown. Thus, we aimed to compare patterns of CC change in patients with rMTLE and benign MTLE (bMTLE), the latter of which represents a useful resource to better disentangle factors that contribute to refractoriness. METHODS: The study group included 79 patients with bMTLE (mean age 43.2 ± 14. 8 years), 61 with rMTLE (mean age 45.2 ± 12.4 years) and 134 healthy volunteers. Structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were performed to measure thickness, mean diffusivity (MD), and fractional anisotropy (FA) over 50 regions of interest along the cross-sectional CC profile. Statistical analysis comprised analysis of variance (ANOVA) followed by post hoc Tukey's Honest Significant Difference test. RESULTS: We found that all imaging metrics of the CC splenium were altered in rMTLE patients compared to bMTLE and controls. We also found significantly reduced thickness and FA of the anterior CC in rMTLE compared to controls and that FA was reduced only in rMTLE compared to bMTLE. Patients with bMTLE did not differ from controls. Differences between disease subgroups were found in the midbody composed of sensorimotor fibers. SIGNIFICANCE: We found altered multimodal imaging metrics of the CC in rMTLE but not in bMTLE. These findings were independent of the radiologic presence of hippocampal sclerosis, suggesting that differences in the distribution of such alterations might be related to refractoriness. Wiley Periodicals, Inc.
Authors: Tobias Bauer; Leon Ernst; Bastian David; Albert J Becker; Jan Wagner; Juri-Alexander Witt; Christoph Helmstaedter; Bernd Weber; Elke Hattingen; Christian E Elger; Rainer Surges; Theodor Rüber Journal: Neuroimage Clin Date: 2020-05-26 Impact factor: 4.881
Authors: Sean N Hatton; Khoa H Huynh; Leonardo Bonilha; Eugenio Abela; Saud Alhusaini; Andre Altmann; Marina K M Alvim; Akshara R Balachandra; Emanuele Bartolini; Benjamin Bender; Neda Bernasconi; Andrea Bernasconi; Boris Bernhardt; Núria Bargallo; Benoit Caldairou; Maria E Caligiuri; Sarah J A Carr; Gianpiero L Cavalleri; Fernando Cendes; Luis Concha; Esmaeil Davoodi-Bojd; Patricia M Desmond; Orrin Devinsky; Colin P Doherty; Martin Domin; John S Duncan; Niels K Focke; Sonya F Foley; Antonio Gambardella; Ezequiel Gleichgerrcht; Renzo Guerrini; Khalid Hamandi; Akari Ishikawa; Simon S Keller; Peter V Kochunov; Raviteja Kotikalapudi; Barbara A K Kreilkamp; Patrick Kwan; Angelo Labate; Soenke Langner; Matteo Lenge; Min Liu; Elaine Lui; Pascal Martin; Mario Mascalchi; José C V Moreira; Marcia E Morita-Sherman; Terence J O'Brien; Heath R Pardoe; José C Pariente; Letícia F Ribeiro; Mark P Richardson; Cristiane S Rocha; Raúl Rodríguez-Cruces; Felix Rosenow; Mariasavina Severino; Benjamin Sinclair; Hamid Soltanian-Zadeh; Pasquale Striano; Peter N Taylor; Rhys H Thomas; Domenico Tortora; Dennis Velakoulis; Annamaria Vezzani; Lucy Vivash; Felix von Podewils; Sjoerd B Vos; Bernd Weber; Gavin P Winston; Clarissa L Yasuda; Alyssa H Zhu; Paul M Thompson; Christopher D Whelan; Neda Jahanshad; Sanjay M Sisodiya; Carrie R McDonald Journal: Brain Date: 2020-08-01 Impact factor: 13.501