Anat Berkovitch1, Shaye Kivity2, Robert Klempfner3, Shlomo Segev4, Assi Milwidsky5, Aharon Erez3, Avi Sabbag3, Ilan Goldenberg3, Yechezkel Sidi6, Elad Maor7. 1. Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel; Department of Internal Medicine D, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. 2. Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Department of Internal Medicine C, Chaim Sheba Medical Center, Tel Hashomer, Israel; Pinchas Borenstein Talpiot Medical Leadership Program, Chaim Sheba Medical Center, Tel Hashomer, Israel; Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel. 3. Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. 4. Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Institute for Medical Screening, Chaim Sheba Medical Center, Tel Hashomer, Israel. 5. Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Department of Internal Medicine "E," Tel-Aviv Medical Center, Tel Aviv, Israel. 6. Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Department of Internal Medicine C, Chaim Sheba Medical Center, Tel Hashomer, Israel. 7. Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Pinchas Borenstein Talpiot Medical Leadership Program, Chaim Sheba Medical Center, Tel Hashomer, Israel. Electronic address: Elad.Maor@sheba.health.gov.il.
Abstract
BACKGROUND: Increased body mass index (BMI) and obesity are associated with increased risk of new-onset atrial fibrillation (AF) among middle-aged adults. OBJECTIVES: The objective of the study is to investigate the association between BMI and the risk for new-onset AF among middle-aged adults. METHODS: We investigated 18,290 men and women who were annually screened in a tertiary medical center. Participants were divided at baseline into 3 groups: normal weight (BMI ≥18 and <25 kg/m(2), n = 7,692), overweight (BMI ≥25 and <30 kg/m(2), n = 8,032), and obese (BMI ≥30 kg/m(2), n = 2,566). The primary end point was new-onset AF during follow-up. RESULTS: Mean age of study population was 49 ± 11 years, and 73% were men. A total of 288 incident events (1.6%) occurred during 6 ± 4 years. Kaplan-Meier survival analysis showed that the cumulative probability of AF at 6 years was highest among obese participants, intermediate among overweight participants, and lowest among participants with normal weight (2.1%, 1.7%, and 0.8% respectively, P < .001). Multivariable Cox regression analysis showed that overweight and obesity were independently associated with increased AF risk (hazard ratio 1.54 [P = .004] and 2.41 [P < .001], respectively). Assessment of BMI change as a time-dependent covariate in the multivariable model showed that each 1 kg/m(2) reduction in BMI during follow-up was associated with a significant 7% reduction in the risk for the occurrence of a first AF event (hazard ratio 0.93, 95% CI 0.88-0.99, P = .019). Consistently, similar analysis showed that each 5-kg weight loss during follow-up was independently associated with a significant 12% reduced risk of new-onset AF (95% CI 0.81-0.98, P = .02). CONCLUSIONS: Our findings suggest that overweight and obesity are associated with increased AF risk, whereas weight reduction is independently associated with reduced risk of de novo AF.
BACKGROUND: Increased body mass index (BMI) and obesity are associated with increased risk of new-onset atrial fibrillation (AF) among middle-aged adults. OBJECTIVES: The objective of the study is to investigate the association between BMI and the risk for new-onset AF among middle-aged adults. METHODS: We investigated 18,290 men and women who were annually screened in a tertiary medical center. Participants were divided at baseline into 3 groups: normal weight (BMI ≥18 and <25 kg/m(2), n = 7,692), overweight (BMI ≥25 and <30 kg/m(2), n = 8,032), and obese (BMI ≥30 kg/m(2), n = 2,566). The primary end point was new-onset AF during follow-up. RESULTS: Mean age of study population was 49 ± 11 years, and 73% were men. A total of 288 incident events (1.6%) occurred during 6 ± 4 years. Kaplan-Meier survival analysis showed that the cumulative probability of AF at 6 years was highest among obeseparticipants, intermediate among overweight participants, and lowest among participants with normal weight (2.1%, 1.7%, and 0.8% respectively, P < .001). Multivariable Cox regression analysis showed that overweight and obesity were independently associated with increased AF risk (hazard ratio 1.54 [P = .004] and 2.41 [P < .001], respectively). Assessment of BMI change as a time-dependent covariate in the multivariable model showed that each 1 kg/m(2) reduction in BMI during follow-up was associated with a significant 7% reduction in the risk for the occurrence of a first AF event (hazard ratio 0.93, 95% CI 0.88-0.99, P = .019). Consistently, similar analysis showed that each 5-kg weight loss during follow-up was independently associated with a significant 12% reduced risk of new-onset AF (95% CI 0.81-0.98, P = .02). CONCLUSIONS: Our findings suggest that overweight and obesity are associated with increased AF risk, whereas weight reduction is independently associated with reduced risk of de novo AF.
Authors: Narat Srivali; Anwar C Chahal; Meghna P Mansukhani; Jay Mandrekar; Virend K Somers; Sean M Caples Journal: J Clin Sleep Med Date: 2019-10-15 Impact factor: 4.062
Authors: Patrick L Stafford; Evan K Harmon; Paras Patel; McCall Walker; Gen-Min Lin; Seung-Jung Park; Neal A Chatterjee; Nishaki K Mehta; Sula Mazimba; Kenneth Bilchick; Younghoon Kwon Journal: Sleep Med Res Date: 2021-06-24
Authors: Sarah C Conner; Sara Lodi; Kathryn L Lunetta; Juan P Casas; Steven A Lubitz; Patrick T Ellinor; Christopher D Anderson; Qiuxi Huang; Justin Coleman; Wendy B White; Emelia J Benjamin; Ludovic Trinquart Journal: J Am Heart Assoc Date: 2019-08-08 Impact factor: 5.501
Authors: Steffen Blum; Stefanie Aeschbacher; Pascal Meyre; Leon Zwimpfer; Tobias Reichlin; Jürg H Beer; Peter Ammann; Angelo Auricchio; Richard Kobza; Paul Erne; Giorgio Moschovitis; Marcello Di Valentino; Dipen Shah; Jürg Schläpfer; Selina Henz; Christine Meyer-Zürn; Laurent Roten; Matthias Schwenkglenks; Christian Sticherling; Michael Kühne; Stefan Osswald; David Conen Journal: J Am Heart Assoc Date: 2019-10-08 Impact factor: 5.501