Su-Hyun Kim1, Kichang Kwak2, In Hye Jeong1, Jae-Won Hyun1, Hyo-Jin Jo1, AeRan Joung1, Eun-Seung Yu3, Ji-Hee Kim1, Sang Hyun Lee4, Sooin Yun5, Jungnam Joo5, Dong-Kyun Lee2, Jong-Min Lee2, Ho Jin Kim6. 1. Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea. 2. Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea. 3. Mental Health Clinic, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea. 4. Department of Radiology, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea. 5. Biometric Research Branch, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea. 6. Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea hojinkim@ncc.re.kr.
Abstract
OBJECTIVE: To compare the frequency and pattern of cognitive impairment (CI) between patients with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). METHODS: A total of 82 NMOSD patients, 58 MS patients, and 45 healthy controls (HCs) underwent a neuropsychological assessment. RESULTS: CI was observed in 29% of NMOSD and 50% of MS patients (p < 0.001); CI was considered present if a patient scored lower than the fifth percentile compared with HCs in at least three domains. A lower frequency of CI was consistently found when CI was indicated by at least two failed tests (p < 0.001). MS patients performed worse than did NMOSD patients on verbal learning and verbal and visual memory tests. Levels of education and depression and the interval from disease onset to treatment were associated with a negative influence on cognition in patients with NMOSD. CONCLUSION: CI in patients with NMOSD may be not as common as in patients with MS. MS patients exhibited severe impairment, particularly on learning and memory tests, compared with NMOSD patients. Differential prevalence and patterns of CI between NMOSD and MS patients suggest that the two diseases have different mechanisms of brain injury.
OBJECTIVE: To compare the frequency and pattern of cognitive impairment (CI) between patients with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). METHODS: A total of 82 NMOSD patients, 58 MSpatients, and 45 healthy controls (HCs) underwent a neuropsychological assessment. RESULTS: CI was observed in 29% of NMOSD and 50% of MSpatients (p < 0.001); CI was considered present if a patient scored lower than the fifth percentile compared with HCs in at least three domains. A lower frequency of CI was consistently found when CI was indicated by at least two failed tests (p < 0.001). MSpatients performed worse than did NMOSD patients on verbal learning and verbal and visual memory tests. Levels of education and depression and the interval from disease onset to treatment were associated with a negative influence on cognition in patients with NMOSD. CONCLUSION: CI in patients with NMOSD may be not as common as in patients with MS. MSpatients exhibited severe impairment, particularly on learning and memory tests, compared with NMOSD patients. Differential prevalence and patterns of CI between NMOSD and MSpatients suggest that the two diseases have different mechanisms of brain injury.
Authors: Elisabet Lopez-Soley; Jose E Meca-Lallana; Sara Llufriu; Yolanda Blanco; Rocío Gómez-Ballesteros; Jorge Maurino; Francisco Pérez-Miralles; Lucía Forero; Carmen Calles; María L Martinez-Gines; Inés Gonzalez-Suarez; Sabas Boyero; Lucía Romero-Pinel; Ángel P Sempere; Virginia Meca-Lallana; Luis Querol; Lucienne Costa-Frossard; Maria Sepulveda; Elisabeth Solana Journal: J Pers Med Date: 2022-05-02
Authors: Su-Hyun Kim; Eun Young Park; Boram Park; Jae-Won Hyun; Na Young Park; AeRan Joung; Sang Hyun Lee; Ho Jin Kim Journal: Sci Rep Date: 2017-08-23 Impact factor: 4.379