Nitwara Wikan1, Yupin Suputtamongkol2, Sutee Yoksan1, Duncan R Smith3, Prasert Auewarakul2. 1. Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand. 2. Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. 3. Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand. Electronic address: duncan_r_smith@hotmail.com.
Abstract
OBJECTIVE: To identify immunological evidence of Zika virus transmission in Thailand. METHODS: To undertake a preliminary serosurvey of possible exposure to Zika virus, 21 serum samples from cohort of acute undifferentiated fever patients were examined for immunoreactivity to Zika, Dengue, Japanese encephalitis and Chikungunya envelope antigens by Western blot analysis. RESULTS: Twenty of the 21 serum samples showed immunoreactivity to at least one of the antigens, with seven samples showing immunoreactivity to all antigens. Of particular note, two serum samples showed immunoreactivity only to Zika envelope antigen, with no immunoreactivity to other envelope antigens. CONCLUSIONS: This study presents the first evidence of Zika virus transmission in Thailand, although as yet the relationship between transmission and possible cases of Zika fever in Thailand requires further investigation.
OBJECTIVE: To identify immunological evidence of Zika virus transmission in Thailand. METHODS: To undertake a preliminary serosurvey of possible exposure to Zika virus, 21 serum samples from cohort of acute undifferentiated feverpatients were examined for immunoreactivity to Zika, Dengue, Japanese encephalitis and Chikungunya envelope antigens by Western blot analysis. RESULTS: Twenty of the 21 serum samples showed immunoreactivity to at least one of the antigens, with seven samples showing immunoreactivity to all antigens. Of particular note, two serum samples showed immunoreactivity only to Zika envelope antigen, with no immunoreactivity to other envelope antigens. CONCLUSIONS: This study presents the first evidence of Zika virus transmission in Thailand, although as yet the relationship between transmission and possible cases of Zika fever in Thailand requires further investigation.
Authors: Lalita Priyamvada; Kendra M Quicke; William H Hudson; Nattawat Onlamoon; Jaturong Sewatanon; Srilatha Edupuganti; Kovit Pattanapanyasat; Kulkanya Chokephaibulkit; Mark J Mulligan; Patrick C Wilson; Rafi Ahmed; Mehul S Suthar; Jens Wrammert Journal: Proc Natl Acad Sci U S A Date: 2016-06-27 Impact factor: 11.205
Authors: Matthew T Aliota; Leda Bassit; Shelton S Bradrick; Bryan Cox; Mariano A Garcia-Blanco; Christina Gavegnano; Thomas C Friedrich; Thaddeus G Golos; Diane E Griffin; Andrew D Haddow; Esper G Kallas; Uriel Kitron; Marc Lecuit; Diogo M Magnani; Caroline Marrs; Natalia Mercer; Edward McSweegan; Lisa F P Ng; David H O'Connor; Jorge E Osorio; Guilherme S Ribeiro; Michael Ricciardi; Shannan L Rossi; George Saade; Raymond F Schinazi; Geraldine O Schott-Lerner; Chao Shan; Pei-Yong Shi; David I Watkins; Nikos Vasilakis; Scott C Weaver Journal: Antiviral Res Date: 2017-06-06 Impact factor: 5.970