Literature DB >> 26919418

Hedgehog Pathway Inhibition.

Aleksandar Sekulic1, Daniel Von Hoff2.   

Abstract

The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 26919418     DOI： 10.1016/j.cell.2016.02.021

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  29 in total

1.  Epigenetic markers in basal cell carcinoma: universal themes in oncogenesis and tumor stratification? - a short report.

Authors:  Rajesh C Rao; May P Chan; Chris A Andrews; Alon Kahana
Journal:  Cell Oncol (Dordr)       Date:  2018-09-13       Impact factor: 6.730

2.  Germline SUFU mutation carriers and medulloblastoma: clinical characteristics, cancer risk, and prognosis.

Authors:  Léa Guerrini-Rousseau; Christelle Dufour; Pascale Varlet; Julien Masliah-Planchon; Franck Bourdeaut; Marine Guillaud-Bataille; Rachid Abbas; Anne-Isabelle Bertozzi; Fanny Fouyssac; Sophie Huybrechts; Stéphanie Puget; Brigitte Bressac-De Paillerets; Olivier Caron; Nicolas Sevenet; Marina Dimaria; Sophie Villebasse; Olivier Delattre; Dominique Valteau-Couanet; Jacques Grill; Laurence Brugières
Journal:  Neuro Oncol       Date:  2018-07-05       Impact factor: 12.300

3.  Repurposing itraconazole for the treatment of cancer.

Authors:  Rachel Pounds; Sarah Leonard; Christopher Dawson; Sean Kehoe
Journal:  Oncol Lett       Date:  2017-07-10       Impact factor: 2.967

Review 4.  Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy.

Authors:  Ekaterina Pak; Rosalind A Segal
Journal:  Dev Cell       Date:  2016-08-22       Impact factor: 12.270

5.  Multiple nonsyndromic acquired basal cell carcinomas : Uncommon clinical presentation in a Bulgarian patient.

Authors:  Georgi Tchernev; Ivan Pidakev; Ilia Lozev; Torello Lotti; Uwe Wollina
Journal:  Wien Med Wochenschr       Date:  2017-02-20

Review 6.  Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer.

Authors:  Jihoon W Lee; Kajan Ratnakumar; Kai-Feng Hung; Daiki Rokunohe; Masaoki Kawasumi
Journal:  Photochem Photobiol       Date:  2020-05-04       Impact factor: 3.421

7.  Hedgehog signaling promotes endoneurial fibroblast migration and Vegf-A expression following facial nerve injury.

Authors:  C Faniku; W Kong; L He; M Zhang; G Lilly; J P Pepper
Journal:  Brain Res       Date:  2020-11-12       Impact factor: 3.252

8.  Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma.

Authors:  Silvia Pietrobono; Eugenio Gaudio; Sinforosa Gagliardi; Mariapaola Zitani; Laura Carrassa; Francesca Migliorini; Elena Petricci; Fabrizio Manetti; Nikolai Makukhin; Adam G Bond; Brooke D Paradise; Alessio Ciulli; Martin E Fernandez-Zapico; Francesco Bertoni; Barbara Stecca
Journal:  Oncogene       Date:  2021-05-06       Impact factor: 9.867

9.  Keratinocytes from Gorlin Syndrome-induced pluripotent stem cells are resistant against UV radiation.

Authors:  Nana Morita; Shoko Onodera; Yuriko Nakamura; Takashi Nakamura; Shin-Ichi Takahashi; Takeshi Nomura; Toshifumi Azuma
Journal:  Med Mol Morphol       Date:  2020-08-20       Impact factor: 2.309

10.  HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53.

Authors:  Xuming Zhu; Matthew Leboeuf; Fang Liu; Marina Grachtchouk; John T Seykora; Edward E Morrisey; Andrzej A Dlugosz; Sarah E Millar
Journal:  J Invest Dermatol       Date:  2021-07-18       Impact factor: 8.551
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