| Literature DB >> 269161 |
H L Vahlsing, S K Kim, E R Feringa.
Abstract
A single injection of 75 mg/kg cyclophosphamide caused gross dental abnormalities in rats. Broken, malformed, overgrown, and "extra" incisors developed several weeks after drug treatment. Radioautographic investigations show no unusual features in the morphology or labeling with H3-thymidine in the odontogenic cells. The results suggest that the cytotoxic effect of the drug is a temporary one which induces a residual alteration of tooth growth.Entities:
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Year: 1977 PMID： 269161 DOI： 10.1177/00220345770560071601
Source DB: PubMed Journal: J Dent Res ISSN： 0022-0345 Impact factor: 6.116