BACKGROUND: The imidazole nucleus is inimitable and ubiquitous and it is very well known to play an important role in living organisms. Imidazole derivatives are under intensive scientific exploration due to their diverse and significant pharmacological activities. METHODS: The present paper is an attempt to discuss chemistry, synthetic aspects including click chemistry procedures of imidazoles through systematic literature survey. RESULTS: Biological activity profiles of the imidazole derivatives reported in recent scientific literature from 2000 to 2015 have been discussed in detail. It has been found that imidazole derivatives depict appreciable antiinfective activity potential. CONCLUSION: It is anticipated that the information compiled in this paper will be useful and motivating to prospective researchers working on this heterocylic scaffold.
BACKGROUND: The imidazole nucleus is inimitable and ubiquitous and it is very well known to play an important role in living organisms. Imidazole derivatives are under intensive scientific exploration due to their diverse and significant pharmacological activities. METHODS: The present paper is an attempt to discuss chemistry, synthetic aspects including click chemistry procedures of imidazoles through systematic literature survey. RESULTS: Biological activity profiles of the imidazole derivatives reported in recent scientific literature from 2000 to 2015 have been discussed in detail. It has been found that imidazole derivatives depict appreciable antiinfective activity potential. CONCLUSION: It is anticipated that the information compiled in this paper will be useful and motivating to prospective researchers working on this heterocylic scaffold.
Authors: Natalia Andersen; Tania Veuthey; María Gabriela Blanco; Gustavo Fabian Silbestri; Diego Rayes; María José De Rosa Journal: Front Pharmacol Date: 2022-05-24 Impact factor: 5.988
Authors: María Gabriela Blanco; María Soledad Vela Gurovic; Gustavo Fabián Silbestri; Andrés Garelli; Sebastián Giunti; Diego Rayes; María José De Rosa Journal: PLoS Negl Trop Dis Date: 2018-12-17