Jun Li1,2, Chao Zhang1,2, Jie-Bing Wang1,2, Shuang-Shuang Chen1,2, Tian-Ping Zhang1,2, Si Li1,2, Hai-Feng Pan1,2, Dong-Qing Ye1,2. 1. a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , P.R. China and. 2. b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , P.R. China.
Abstract
OBJECTIVES: The purpose of this study was to evaluate whether a single-nucleotide polymorphism (SNP) IL12B 3(')UTR +1188A/C (rs3212227) confers susceptibility to several autoimmune diseases. METHODS: A systematic literature search was conducted to identify relevant studies. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to estimate the strength of association. RESULTS: Twenty-five studies were included in the meta-analysis, which contained 9794 cases and 11,330 controls. Our result indicated that IL12B +1188A/C (rs3212227) polymorphism was associated with type-1 diabetes (T1D) in the dominant model (p = 0.008), and an increased risk was found in East Asians in the dominant model (p < 0.001). East Asians rheumatoid arthritis (RA) patients seemed to be at risk of allelic model (p = 0.011). As to Behcet's disease (BD), there was a risk in dominant model (p = 0.020) and positive associations of dominant model, allelic model in East Asians (p = 0.009; p < 0.001, respectively). But we failed to find any association between IL12B +1188A/C (rs3212227) polymorphism with Graves' disease (GD) and ankylosing spondylitis (AS). CONCLUSIONS: The present study suggests that the IL12B +1188A/C (rs3212227) polymorphism might be associated with genetic susceptibility to autoimmune diseases, such as T1D, RA, BD, but not GD and AS.
OBJECTIVES: The purpose of this study was to evaluate whether a single-nucleotide polymorphism (SNP) IL12B 3(')UTR +1188A/C (rs3212227) confers susceptibility to several autoimmune diseases. METHODS: A systematic literature search was conducted to identify relevant studies. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to estimate the strength of association. RESULTS: Twenty-five studies were included in the meta-analysis, which contained 9794 cases and 11,330 controls. Our result indicated that IL12B+1188A/C (rs3212227) polymorphism was associated with type-1 diabetes (T1D) in the dominant model (p = 0.008), and an increased risk was found in East Asians in the dominant model (p < 0.001). East Asians rheumatoid arthritis (RA) patients seemed to be at risk of allelic model (p = 0.011). As to Behcet's disease (BD), there was a risk in dominant model (p = 0.020) and positive associations of dominant model, allelic model in East Asians (p = 0.009; p < 0.001, respectively). But we failed to find any association between IL12B+1188A/C (rs3212227) polymorphism with Graves' disease (GD) and ankylosing spondylitis (AS). CONCLUSIONS: The present study suggests that the IL12B+1188A/C (rs3212227) polymorphism might be associated with genetic susceptibility to autoimmune diseases, such as T1D, RA, BD, but not GD and AS.
Authors: Jan Dimberg; Marie Rubér; Marita Skarstedt; Manne Andersson; Roland E Andersson Journal: Int J Colorectal Dis Date: 2019-12-16 Impact factor: 2.571
Authors: Patricia S Graham; Georgia Kaidonis; Sotoodeh Abhary; Mark C Gillies; Mark Daniell; Rohan W Essex; John H Chang; Stewart R Lake; Bishwanath Pal; Alicia J Jenkins; Alex W Hewitt; Ecosse L Lamoureux; Philip G Hykin; Nikolai Petrovsky; Matthew A Brown; Jamie E Craig; Kathryn P Burdon Journal: BMC Med Genet Date: 2018-05-08 Impact factor: 2.103