Elodie Bousquet1, Myriam Dhundass2, Mathieu Lehmann2, Pierre-Raphaël Rothschild3, Virginie Bayon4, Damien Leger4, Ciara Bergin5, Ali Dirani5, Talal Beydoun2, Francine Behar-Cohen6. 1. Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France; Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France. Electronic address: bousquetelodie@hotmail.fr. 2. Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France. 3. Department of Ophthalmology, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France; Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France. 4. Sleep and Vigilance Center, Hôtel-Dieu of Paris, Assistance Publique-Hôpitaux de Paris, AP-HP, Paris, France, Université Sorbonne Paris Cité, Paris, France. 5. Department of Ophthalmology University of Lausanne, Jules Gonin Ophthalmic Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland. 6. Inserm U1138, Team 17, Université Sorbonne Paris Cité, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France; Department of Ophthalmology University of Lausanne, Jules Gonin Ophthalmic Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.
Abstract
PURPOSE: To investigate if shift work or sleep disturbances are risk factors for central serous chorioretinopathy (CSCR). DESIGN: Prospective case-control study. METHODS: Forty patients with active CSCR and 40 controls (age- and sex-matched) were prospectively recruited from the Ophthalmology Department of Hôtel Dieu Hospital, Paris, between November 2013 and December 2014. All patients were asked to complete a questionnaire addressing previously described risk factors and working hours, as well as the Insomnia Severity Index (ISI), a validated instrument for assessing sleep disturbances. RESULTS: The mean age of the CSCR group was 44 ± 9 years, whereas the mean age of the control group was 43 ± 10 years. By use of multivariate analysis, shift work (odds ratio [OR] [95% confidence interval]: 5 [1.2-20.4]; P = .02), steroid use (OR: 5.5 [1.1-26.2]; P = .03), and recent psychological stress (OR: 15.3 [4.1-54.5]; P < .001) were found to be independently associated with CSCR. CONCLUSION: The outcomes of this study suggest that shift work is an independent risk factor of CSCR. Further studies are required to confirm these results and to examine if work reconversion would be beneficial in the treatment of patients with chronic/recurrent CSCR.
PURPOSE: To investigate if shift work or sleep disturbances are risk factors for central serous chorioretinopathy (CSCR). DESIGN: Prospective case-control study. METHODS: Forty patients with active CSCR and 40 controls (age- and sex-matched) were prospectively recruited from the Ophthalmology Department of Hôtel Dieu Hospital, Paris, between November 2013 and December 2014. All patients were asked to complete a questionnaire addressing previously described risk factors and working hours, as well as the Insomnia Severity Index (ISI), a validated instrument for assessing sleep disturbances. RESULTS: The mean age of the CSCR group was 44 ± 9 years, whereas the mean age of the control group was 43 ± 10 years. By use of multivariate analysis, shift work (odds ratio [OR] [95% confidence interval]: 5 [1.2-20.4]; P = .02), steroid use (OR: 5.5 [1.1-26.2]; P = .03), and recent psychological stress (OR: 15.3 [4.1-54.5]; P < .001) were found to be independently associated with CSCR. CONCLUSION: The outcomes of this study suggest that shift work is an independent risk factor of CSCR. Further studies are required to confirm these results and to examine if work reconversion would be beneficial in the treatment of patients with chronic/recurrent CSCR.
Authors: Camila Q Felipe; Ana Luiza Biancardi; Vinicius T Civile; Nelson Carvas Junior; Pedro D Serracarbassa; Marcia K Koike Journal: Int J Retina Vitreous Date: 2022-06-07