E Bertelli1, S Leonini2, D Galimberti3, S Moretti3, R Tinturini4, T Hadjistilianou5, S De Francesco5, D G Romano2, I M Vallone2, S Cioni2, P Gennari2, P Galluzzi2, I Grazzini2, S Rossi1, S Bracco6. 1. From the Department of Molecular and Developmental Medicine (E.B., S.R.), University of Siena, Siena, Italy. 2. Units of Neuroimaging and Neurointervention (S.L., D.G.R., I.M.V., S.C., P. Gennari, P. Galluzzi, I.G., S.B.). 3. Pediatrics (D.G., S.M.). 4. Neurosurgical Intensive Care (R.T.), Azienda Ospedaliera Universitaria Senese, University of Siena, Policlinico "Santa Maria alle Scotte," Siena, Italy. 5. Department of Medicine, Surgery and Neuroscience (T.H., S.D.F.), Unit of Ophthalmology, University of Siena, Policlinico "Santa Maria alle Scotte," Siena, Italy. 6. Units of Neuroimaging and Neurointervention (S.L., D.G.R., I.M.V., S.C., P. Gennari, P. Galluzzi, I.G., S.B.) sandrabracco64@gmail.com.
Abstract
BACKGROUND AND PURPOSE: Intra-arterial chemotherapy for retinoblastoma is not always a straightforward procedure, and it may require an adaptable approach. This study illustrates strategies used when the ophthalmic artery is difficult to catheterize or not visible, and it ascertains the effectiveness and safety of these strategies. MATERIALS AND METHODS: A retrospective study was performed on a series of 108 eyes affected by intraocular retinoblastoma and selected for intra-arterial chemotherapy (follow-up range, 6-82 months). We recognized 3 different patterns of drug delivery: a fixed pattern through the ophthalmic artery, a fixed pattern through branches of the external carotid artery, and a variable pattern through either the ophthalmic or the external carotid artery. RESULTS: We performed 448 sessions of intra-arterial chemotherapy, 83.70% of them through the ophthalmic artery and 16.29% via the external carotid artery. In 24.52% of eyes, the procedure was performed at least once through branches of the external carotid artery. In 73 eyes, the pattern of drug delivery was fixed through the ophthalmic artery; for 9 eyes, it was fixed through branches of the external carotid artery; and for 17 eyes, the pattern was variable. Statistical analysis did not show any significant difference in the clinical outcome of the eyes (remission versus enucleation) treated with different patterns of drug delivery. Adverse events could not be correlated with any particular pattern. CONCLUSIONS: Alternative routes of intra-arterial chemotherapy for intraocular retinoblastoma appear in the short term as effective and safe as the traditional drug infusion through the ophthalmic artery.
BACKGROUND AND PURPOSE: Intra-arterial chemotherapy for retinoblastoma is not always a straightforward procedure, and it may require an adaptable approach. This study illustrates strategies used when the ophthalmic artery is difficult to catheterize or not visible, and it ascertains the effectiveness and safety of these strategies. MATERIALS AND METHODS: A retrospective study was performed on a series of 108 eyes affected by intraocular retinoblastoma and selected for intra-arterial chemotherapy (follow-up range, 6-82 months). We recognized 3 different patterns of drug delivery: a fixed pattern through the ophthalmic artery, a fixed pattern through branches of the external carotid artery, and a variable pattern through either the ophthalmic or the external carotid artery. RESULTS: We performed 448 sessions of intra-arterial chemotherapy, 83.70% of them through the ophthalmic artery and 16.29% via the external carotid artery. In 24.52% of eyes, the procedure was performed at least once through branches of the external carotid artery. In 73 eyes, the pattern of drug delivery was fixed through the ophthalmic artery; for 9 eyes, it was fixed through branches of the external carotid artery; and for 17 eyes, the pattern was variable. Statistical analysis did not show any significant difference in the clinical outcome of the eyes (remission versus enucleation) treated with different patterns of drug delivery. Adverse events could not be correlated with any particular pattern. CONCLUSIONS: Alternative routes of intra-arterial chemotherapy for intraocular retinoblastoma appear in the short term as effective and safe as the traditional drug infusion through the ophthalmic artery.
Authors: Bruno Bartolini; Francesco Puccinelli; Steven D Hajdu; Christina Stathopoulos; Maja Beck-Popovic; Francis L Munier; Guillaume Saliou Journal: Interv Neuroradiol Date: 2018-11-28 Impact factor: 1.610
Authors: Adrián Valls Carbó; María Gutiérrez Sánchez de la Fuente; Carlos Pérez García; Maria Natividad Gómez Ruiz Journal: BMJ Case Rep Date: 2020-05-05
Authors: T Abruzzo; K Abraham; K B Karani; J I Geller; S Vadivelu; J M Racadio; B Zhang; Z M Correa Journal: AJNR Am J Neuroradiol Date: 2020-12-24 Impact factor: 3.825