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Literature DB >> 26914527

I2-Catalyzed Oxidative Coupling Reactions of Hydrazones and Amines and the Application in the Synthesis of 1,3,5-Trisubstituted 1,2,4-Triazoles.

Zhengkai Chen¹, Hongli Li¹, Weipeng Dong¹, Maozhong Miao¹, Hongjun Ren¹.

Abstract

A general and expeditious approach for the metal-free mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles from hydrazones and aliphatic amines has been achieved under aerobic oxidative conditions. The reaction proceeds through a cascade C-H functionalization, double C-N bonds formation, and oxidative aromatization sequence.

Entities: Chemical

Year: 2016 PMID： 26914527 DOI： 10.1021/acs.orglett.6b00277

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

6 in total

1. A synthesis of functionalized 3-amino-1,2,4-triazoles from nitrile imines and guanidine derivatives.

Authors: Issa Yavari; Zohreh Taheri; Sara Sheikhi
Journal: Mol Divers Date: 2022-07-17 Impact factor: 3.364

2. Rapid Synthesis of N-Tosylhydrazones under Solvent-Free Conditions and Their Potential Application Against Human Triple-Negative Breast Cancer.

Authors: Zengyang Xie; Yuying Song; Lujia Xu; Yukun Guo; Min Zhang; Limei Li; Kai Chen; Xue Liu
Journal: ChemistryOpen Date: 2018-11-21 Impact factor: 2.911

3. An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4-Triazole Scaffold Cyclic Compounds.

Authors: Wangyu Li; Mingteng Xiong; Xiao Liang; Dungai Wang; Heping Zhu; Yuanjiang Pan
Journal: ChemistryOpen Date: 2022-01 Impact factor: 2.911

I2-Catalyzed Oxidative Coupling Reactions of Hydrazones and Amines and the Application in the Synthesis of 1,3,5-Trisubstituted 1,2,4-Triazoles.

1. A synthesis of functionalized 3-amino-1,2,4-triazoles from nitrile imines and guanidine derivatives.

2. Rapid Synthesis of N-Tosylhydrazones under Solvent-Free Conditions and Their Potential Application Against Human Triple-Negative Breast Cancer.

3. An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4-Triazole Scaffold Cyclic Compounds.

Review 4. Novel 1, 2, 4-Triazoles as Antifungal Agents.

Review 5. Synthesis methods of 1,2,3-/1,2,4-triazoles: A review.

Review 6. Triazole analogues as potential pharmacological agents: a brief review.