| Literature DB >> 26913941 |
Patrícia O Figueiredo1, Maria de Fatima C Matos2, Renata T Perdomo2, Wilson H Kato1, Marcos Vinícius G O Barros1, Fernanda R Garcez1, Walmir S Garcez1.
Abstract
Two Rubiaceae-type cyclopeptides, 6-O-methylbouvardin (1) and the new cyclopeptide 5β-hydroxy-RA-III (2), were isolated from the roots of Galianthe thalictroides. Employing the sulforhodamine B assay, compounds 1 and 2 were tested in vitro against three cancer cell lines--786-0 (kidney carcinoma), PC-3 (prostate carcinoma), and HT-29 (colon carcinoma)--and showed GI50 values ranging from 0.06 to 1.80 μg mL(-1). This is the first report on the isolation of Rubiaceae-type cyclopeptides from a genus other than Rubia or Bouvardia.Entities:
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Year: 2016 PMID： 26913941 DOI： 10.1021/acs.jnatprod.5b00849
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050