Literature DB >> 2691339

The nucleotide sequence of a mouse renin-encoding gene, Ren-1d, and its upstream region.

D W Burt1, L J Mullins, H George, G Smith, J Brooks, D Pioli, W J Brammar.   

Abstract

The renin-encoding genes have been cloned from high (Ren-1d, Ren-2d)- and low (Ren-1c)-renin-producing strains of mice (DBA/2J and C57BL/10). Each of the genes is approx. 9.6 kb in length and consists of nine exons and eight introns. The entire nucleotide sequence of the Ren-1d gene has been determined and the 5'-flanking regions of the three genes, Ren-1c, Ren-1d and Ren-2d, have been compared. The significance of several potential regulatory signals found in the DNA is discussed.

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Year:  1989        PMID： 2691339     DOI： 10.1016/0378-1119(89)90143-1

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  8 in total

1.  A combination of upstream and proximal elements is required for efficient expression of the mouse renin promoter in cultured cells.

Authors:  K Tamura; K Tanimoto; K Murakami; A Fukamizu
Journal:  Nucleic Acids Res       Date:  1992-07-25       Impact factor: 16.971

2.  Identification of a negative regulatory element involved in tissue-specific expression of mouse renin genes.

Authors:  G Barrett; M Horiuchi; M Paul; R E Pratt; N Nakamura; V J Dzau
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-01       Impact factor: 11.205

3.  Targeted integration of the Ren-1D locus in mouse embryonic stem cells.

Authors:  C C Miller; J C McPheat; W J Potts
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

4.  Normotensive blood pressure in mice with a disrupted renin Ren-1d gene.

Authors:  F Bertaux; W H Colledge; S E Smith; M Evans; N J Samani; C C Miller
Journal:  Transgenic Res       Date:  1997-05       Impact factor: 2.788

5.  Elevated blood pressures in mice lacking endothelial nitric oxide synthase.

Authors:  E G Shesely; N Maeda; H S Kim; K M Desai; J H Krege; V E Laubach; P A Sherman; W C Sessa; O Smithies
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

6.  Region-specific rates of molecular evolution: a fourfold reduction in the rate of accumulation of "silent" mutations in transcribed versus nontranscribed regions of homologous DNA fragments derived from two closely related mouse species.

Authors:  M S Turker; G E Cooper; P L Bishop
Journal:  J Mol Evol       Date:  1993-01       Impact factor: 2.395

7.  DNA insertions distinguish the duplicated renin genes of DBA/2 and M. hortulanus mice.

Authors:  K J Abel; P N Howles; K W Gross
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

8.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1990-07-25       Impact factor: 16.971
  8 in total

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