Literature DB >> 26913086

Immune mediated crescentic MPGN secondary to HBV infection: A rare presentation for a common infection.

Aswani Srinivas Mareddy1, Dharshan Rangaswamy1, Mahesha Vankalakunti2, Ravindra Prabhu Attur1, Shankar Prasad Nagaraju1, Neeraja Koti3.   

Abstract

Hepatitis B virus (HBV) infection presenting as crescentic glomerulonephritis in the absence of cryoglobulinemia is an extremely rare phenomenon. We report a case of a 44-year-old male with HBV infection, who underwent kidney biopsy for rapidly progressive renal failure and nephrotic range proteinuria. Histopathological evaluation of the kidney biopsy was consistent with immune complex mediated crescentic membranoproliferative glomerulonephritis (MPGN). The patient achieved complete renal and virological remission with steroids, plasmapheresis and antiviral therapy. This case report summarises the importance of early initiation of immunosuppression and plasmapheresis under antiviral coverage for improved clinical outcomes.

Entities:  

Keywords:  Hepatitis B Virus; MPGN; crescentic glomerulonephritis; crescentic membranoproliferative glomerulonephritis

Year:  2016        PMID: 26913086      PMCID: PMC4748015          DOI: 10.4066/AMJ.2015.2568

Source DB:  PubMed          Journal:  Australas Med J        ISSN: 1836-1935


  18 in total

1.  Transformation of hepatitis B virus-related membranous glomerulonephritis to crescentic form.

Authors:  H Taskapan; O Oymak; A Dogukan; O Ozbakir; C Utas
Journal:  Clin Nephrol       Date:  2000-08       Impact factor: 0.975

2.  Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity.

Authors:  J J Ott; G A Stevens; J Groeger; S T Wiersma
Journal:  Vaccine       Date:  2012-01-24       Impact factor: 3.641

3.  Glomerulonephritis associated with hepatitis-B surface antigen immune complexes in children.

Authors:  W J Brzosko; K Krawczyński; T Nazarewicz; M Morzycka; A Nowoslawski
Journal:  Lancet       Date:  1974-08-31       Impact factor: 79.321

4.  Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane.

Authors:  B Combes; J Shorey; A Barrera; P Stastny; E H Eigenbrodt; A R Hull; N W Carter
Journal:  Lancet       Date:  1971-07-31       Impact factor: 79.321

5.  A renal biopsy study of hepatitis B virus-associated nephropathy in Korea.

Authors:  H S Lee; Y Choi; S H Yu; H I Koh; M J Kim; K W Ko
Journal:  Kidney Int       Date:  1988-10       Impact factor: 10.612

6.  Improvement of hepatitis B-associated glomerulonephritis after antiviral combination therapy.

Authors:  R A de Man; S W Schalm; A J van der Heijden; F W ten Kate; E D Wolff; R A Heijtink
Journal:  J Hepatol       Date:  1989-05       Impact factor: 25.083

7.  Hepatitis B: the virus and disease.

Authors:  T Jake Liang
Journal:  Hepatology       Date:  2009-05       Impact factor: 17.425

8.  Crescentic glomerulonephritis related to hepatitis B virus.

Authors:  F M Lai; P K Li; M W Suen; S F Lui; K N Lai
Journal:  Mod Pathol       Date:  1992-05       Impact factor: 7.842

9.  Determinants of early mortality in patients with decompensated chronic hepatitis B treated with antiviral therapy.

Authors:  Robert J Fontana; Hie-Won L Hann; Robert P Perrillo; John M Vierling; Theresa Wright; Jorge Rakela; Gaya Anschuetz; Randy Davis; Stephen D Gardner; Nathaniel A Brown
Journal:  Gastroenterology       Date:  2002-09       Impact factor: 22.682

10.  Sudden deterioration of renal function in a patient with nephrotic syndrome and a very high hepatitis B viral DNA load.

Authors:  Hamid Nasri; Muhammed Mubarak
Journal:  J Renal Inj Prev       Date:  2012-01-01
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