Mattias Sandström1, Karolina Lindskog2, Irina Velikyan2, Anders Wennborg3, Joachim Feldwisch4, Dan Sandberg2, Vladimir Tolmachev5, Anna Orlova5, Jens Sörensen2, Jörgen Carlsson5, Henrik Lindman6, Mark Lubberink2. 1. Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden mattias.sandstrom@akademiska.se. 2. Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. 3. Affibody AB, Solna, Sweden. 4. Affibody AB, Solna, Sweden Biomedical Radiation Sciences, Rudbeck Laboratory, Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden; and. 5. Biomedical Radiation Sciences, Rudbeck Laboratory, Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden; and. 6. Section of Oncology, Department of Immunology, Genetics, and Pathology, Uppsala, Sweden.
Abstract
UNLABELLED: (68)Ga-ABY-025 is a radiolabeled Affibody molecule for in vivo diagnosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer tumors with PET. The aim of the present work was to measure the biodistribution and estimate the radiation dosimetry of (68)Ga-ABY-025 for 2 different peptide mass doses in a single group of patients using dynamic and serial whole-body PET/CT. METHODS: Eight patients with metastatic breast cancer were included. Each patient underwent an abdominal 45-min dynamic and 3 whole-body PET/CT scans at 1, 2, and 4 h after injection of a low peptide dose (LD) and a high peptide dose (HD), with approximately the same amount of radioactivity, in separate investigations 1 wk apart. As input to the absorbed dose calculations, volumes of interest were drawn on all clearly identifiable source organs: liver, kidneys, spleen, descending aorta, and upper large intestine. Absorbed doses were calculated using OLINDA/EXM, version 1.1. RESULTS: Of the major organs, the highest radionuclide uptake at 1, 2, and 4 h after injection was observed in the kidneys and liver. The highest absorbed organ doses were seen in the kidneys, followed by the liver for both LD and HD (68)Ga-ABY-025. Absorbed doses to liver and kidneys were slightly but significantly higher for LD. Total effective dose was 0.030 ± 0.003 mSv/MBq for LD and 0.028 ± 0.002 mSv/MBq for HD. CONCLUSION: The effective dose for a typical 200-MBq administration of (68)Ga-ABY-025 is 6.0 mSv for LD and 5.6 mSv for HD. Therefore, from a radiation dosimetry point of view, HD is preferred for PET/CT evaluation of HER2-expressing breast cancer tumors. These effective doses are somewhat higher than earlier published values for other (68)Ga-labeled tracers, such as 0.021 ± 0.003 mSv/MBq for (68)Ga-DOTATATE and (68)Ga-DOTATOC, mainly because of higher uptake in liver and kidney.
UNLABELLED: (68)Ga-ABY-025 is a radiolabeled Affibody molecule for in vivo diagnosis of humanepidermal growth factor receptor 2 (HER2)-positive breast cancer tumors with PET. The aim of the present work was to measure the biodistribution and estimate the radiation dosimetry of (68)Ga-ABY-025 for 2 different peptide mass doses in a single group of patients using dynamic and serial whole-body PET/CT. METHODS: Eight patients with metastatic breast cancer were included. Each patient underwent an abdominal 45-min dynamic and 3 whole-body PET/CT scans at 1, 2, and 4 h after injection of a low peptide dose (LD) and a high peptide dose (HD), with approximately the same amount of radioactivity, in separate investigations 1 wk apart. As input to the absorbed dose calculations, volumes of interest were drawn on all clearly identifiable source organs: liver, kidneys, spleen, descending aorta, and upper large intestine. Absorbed doses were calculated using OLINDA/EXM, version 1.1. RESULTS: Of the major organs, the highest radionuclide uptake at 1, 2, and 4 h after injection was observed in the kidneys and liver. The highest absorbed organ doses were seen in the kidneys, followed by the liver for both LD and HD (68)Ga-ABY-025. Absorbed doses to liver and kidneys were slightly but significantly higher for LD. Total effective dose was 0.030 ± 0.003 mSv/MBq for LD and 0.028 ± 0.002 mSv/MBq for HD. CONCLUSION: The effective dose for a typical 200-MBq administration of (68)Ga-ABY-025 is 6.0 mSv for LD and 5.6 mSv for HD. Therefore, from a radiation dosimetry point of view, HD is preferred for PET/CT evaluation of HER2-expressing breast cancer tumors. These effective doses are somewhat higher than earlier published values for other (68)Ga-labeled tracers, such as 0.021 ± 0.003 mSv/MBq for (68)Ga-DOTATATE and (68)Ga-DOTATOC, mainly because of higher uptake in liver and kidney.
Authors: Kimberley S Samkoe; Jason R Gunn; Kayla Marra; Sally M Hull; Karen L Moodie; Joachim Feldwisch; Theresa V Strong; Daniel R Draney; P Jack Hoopes; David W Roberts; Keith Paulsen; Brian W Pogue Journal: Mol Imaging Biol Date: 2017-08 Impact factor: 3.488
Authors: Olga Bragina; Emma von Witting; Javad Garousi; Roman Zelchan; Mattias Sandström; Anna Orlova; Anna Medvedeva; Artem Doroshenko; Anzhelika Vorobyeva; Sarah Lindbo; Jesper Borin; Natalya Tarabanovskaya; Jens Sörensen; Sophia Hober; Vladimir Chernov; Vladimir Tolmachev Journal: J Nucl Med Date: 2020-08-17 Impact factor: 10.057