Oliver S Grosser1, Juri Ruf2, Dennis Kupitz3, Annette Pethe3, Gerhard Ulrich3, Philipp Genseke3, Konrad Mohnike3, Maciej Pech4, Wolf S Richter5, Jens Ricke3, Holger Amthauer3. 1. Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany oliver.grosser@med.ovgu.de. 2. Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany. 3. Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany. 4. Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany 2nd Department of Radiology, Medical University of Gdansk, Gdansk, Poland; and. 5. Pharmtrace-Clinical Research, Berlin, Germany.
Abstract
UNLABELLED: Perfusion scintigraphy using (99m)Tc-labeled albumin aggregates is mandatory before hepatic radioembolization with (90)Y-microspheres. As part of a prospective trial, the intrahepatic and intrapulmonary stability of 2 albumin compounds, (99m)Tc-MAA (macroaggregated serum albumin [MAA]) and (99m)Tc-HSA (human serum albumin [HSA]), was assessed. METHODS: In 24 patients with metastatic colorectal cancer, biodistribution (liver, lung) and liver-lung shunt (LLS) of both tracers (12 patients each) were assessed by sequential planar scintigraphy (1, 5, and 24 h after injection). RESULTS:Liver uptake of both albumin compounds decreased differently. Although initial LLSs at 1 h after injection were similar in both groups, MAA-LLS increased significantly from 1 (3.9%) to 5 h (7.7%) and 24 h (9.9%) after injection, respectively. HSA-LLS did not change significantly (1 to 5 h), indicating a steady state of pulmonary and intrahepatic degradation. CONCLUSION: Compared with (99m)Tc-MAA-microspheres, (99m)Tc-HSA-microspheres are likely more resistant to degradation over time, allowing a reliable LLS determination even at later time points.
RCT Entities:
UNLABELLED: Perfusion scintigraphy using (99m)Tc-labeled albumin aggregates is mandatory before hepatic radioembolization with (90)Y-microspheres. As part of a prospective trial, the intrahepatic and intrapulmonary stability of 2 albumin compounds, (99m)Tc-MAA (macroaggregated serum albumin [MAA]) and (99m)Tc-HSA (human serum albumin [HSA]), was assessed. METHODS: In 24 patients with metastatic colorectal cancer, biodistribution (liver, lung) and liver-lung shunt (LLS) of both tracers (12 patients each) were assessed by sequential planar scintigraphy (1, 5, and 24 h after injection). RESULTS: Liver uptake of both albumin compounds decreased differently. Although initial LLSs at 1 h after injection were similar in both groups, MAA-LLS increased significantly from 1 (3.9%) to 5 h (7.7%) and 24 h (9.9%) after injection, respectively. HSA-LLS did not change significantly (1 to 5 h), indicating a steady state of pulmonary and intrahepatic degradation. CONCLUSION: Compared with (99m)Tc-MAA-microspheres, (99m)Tc-HSA-microspheres are likely more resistant to degradation over time, allowing a reliable LLS determination even at later time points.
Authors: Hugo Levillain; Oreste Bagni; Christophe M Deroose; Arnaud Dieudonné; Silvano Gnesin; Oliver S Grosser; S Cheenu Kappadath; Andrew Kennedy; Nima Kokabi; David M Liu; David C Madoff; Armeen Mahvash; Antonio Martinez de la Cuesta; David C E Ng; Philipp M Paprottka; Cinzia Pettinato; Macarena Rodríguez-Fraile; Riad Salem; Bruno Sangro; Lidia Strigari; Daniel Y Sze; Berlinda J de Wit van der Veen; Patrick Flamen Journal: Eur J Nucl Med Mol Imaging Date: 2021-01-12 Impact factor: 9.236
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Authors: M Weber; M Lam; C Chiesa; M Konijnenberg; M Cremonesi; P Flamen; S Gnesin; L Bodei; T Kracmerova; M Luster; E Garin; K Herrmann Journal: Eur J Nucl Med Mol Imaging Date: 2022-02-11 Impact factor: 9.236
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Authors: Tamar Kapanadze; Jens P Bankstahl; Alexander Wittneben; Wolfgang Koestner; Matthias Ballmaier; Jaba Gamrekelashvili; Kashyap Krishnasamy; Anne Limbourg; Tobias L Ross; Geerd-Jürgen Meyer; Hermann Haller; Frank M Bengel; Florian P Limbourg Journal: Theranostics Date: 2019-01-01 Impact factor: 11.556