Literature DB >> 2691200

Type beta transforming growth factor regulates expression of genes encoding bone matrix proteins.

M Noda1, G A Rodan.   

Abstract

TGF beta modulates the growth and differentiation of various cell types, in part by regulating the production of extracellular matrix proteins. In rat osteoblast-like cells TGF beta stimulates the production of collagen, osteopontin and osteonectin. On the other hand, TGF beta inhibits the production of osteocalcin, one of the most abundant non-collagenous bone matrix proteins, which is only expressed in osteoblasts. Inhibition of osteocalcin expression by TGF beta in the rat osteoblastic osteosarcoma, ROS 17/2.8 cells, occurs at least in part through transcriptional control.

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Year:  1989        PMID： 2691200     DOI： 10.3109/03008208909049997

Source DB:  PubMed          Journal:  Connect Tissue Res        ISSN： 0300-8207            Impact factor:   3.417


  11 in total

1.  Silencing of skeletal metastasis-associated genes impairs migration of breast cancer cells and reduces osteolytic bone lesions.

Authors:  Christina Reufsteck; Rinat Lifshitz-Shovali; Michael Zepp; Tobias Bäuerle; Dieter Kübler; Gershon Golomb; Martin R Berger
Journal:  Clin Exp Metastasis       Date:  2012-03-11       Impact factor: 5.150

2.  Effects of transforming growth factor-beta on collagen synthesis by normal rat kidney epithelial cells.

Authors:  J J Creely; S J DiMari; A M Howe; M A Haralson
Journal:  Am J Pathol       Date:  1992-01       Impact factor: 4.307

3.  Protein kinase signalling pathways involved in the up-regulation of the rat alpha1(I) collagen gene by transforming growth factor beta1 and bone morphogenetic protein 2 in osteoblastic cells.

Authors:  S Palcy; D Goltzman
Journal:  Biochem J       Date:  1999-10-01       Impact factor: 3.857

4.  Promoter hypermethylation of the cysteine protease RECK may cause metastasis of osteosarcoma.

Authors:  Leisheng Wang; Junbo Ge; Tian Ma; Yanpin Zheng; Shiqiao Lv; Yu Li; Shaoxian Liu
Journal:  Tumour Biol       Date:  2015-07-01

5.  Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.

Authors:  C M Giachelli; N Bae; M Almeida; D T Denhardt; C E Alpers; S M Schwartz
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808

6.  Macrophages express osteopontin during repair of myocardial necrosis.

Authors:  C E Murry; C M Giachelli; S M Schwartz; R Vracko
Journal:  Am J Pathol       Date:  1994-12       Impact factor: 4.307

7.  Demonstration of TGF-beta 1 mRNA by in situ hybridization in normal human fracture healing.

Authors:  J G Andrew; J Hoyland; S M Andrew; A J Freemont; D Marsh
Journal:  Calcif Tissue Int       Date:  1993-02       Impact factor: 4.333

8.  A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice.

Authors:  Zouhair Aherrahrou; Susanne B Axtner; Piotr M Kaczmarek; Alexandra Jurat; Susanne Korff; Lars C Doehring; Dieter Weichenhan; Hugo A Katus; Boris T Ivandic
Journal:  Am J Pathol       Date:  2004-04       Impact factor: 4.307

9.  Transforming growth factor-beta mRNA expression and growth control of human ovarian carcinoma cells.

Authors:  J M Bartlett; G J Rabiasz; W N Scott; S P Langdon; J F Smyth; W R Miller
Journal:  Br J Cancer       Date:  1992-05       Impact factor: 7.640

Review 10.  Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis.

Authors:  Christophe Desterke; Christophe Martinaud; Nadira Ruzehaji; Marie-Caroline Le Bousse-Kerdilès
Journal:  Mediators Inflamm       Date:  2015-11-12       Impact factor: 4.711
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