Literature DB >> 26911796

Identification of lysocin E using a silkworm model of bacterial infection.

Hiroshi Hamamoto1, Kazuhisa Sekimizu.   

Abstract

New antimicrobials with novel mechanisms need to be developed to combat antimicrobial-resistant pathogenic bacteria. The current authors recently reported discovery of a new antibiotic named "Lysocin E". Lysocin E was identified using a silkworm model of bacterial infection. The current review discusses the advantages of using a silkworm model of bacterial infection to identify and develop therapeutically efficacious antimicrobials. This review also discusses the discovery of lysocin E and its novel mechanism of action.

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Year:  2016        PMID： 26911796     DOI： 10.5582/ddt.2016.01012

Source DB:  PubMed          Journal:  Drug Discov Ther        ISSN： 1881-7831


  2 in total

1.  Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs.

Authors:  Geberemichal Geberetsadik; Akane Inaizumi; Akihito Nishiyama; Takehiro Yamaguchi; Hiroshi Hamamoto; Suresh Panthee; Aki Tamaru; Manabu Hayatsu; Yusuke Mizutani; Shaban Amina Kaboso; Mariko Hakamata; Aleksandr Ilinov; Yuriko Ozeki; Yoshitaka Tateishi; Kazuhisa Sekimizu; Sohkichi Matsumoto
Journal:  Antimicrob Agents Chemother       Date:  2022-08-15       Impact factor: 5.938

2.  Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E.

Authors:  Hiroaki Itoh; Kotaro Tokumoto; Takuya Kaji; Atmika Paudel; Suresh Panthee; Hiroshi Hamamoto; Kazuhisa Sekimizu; Masayuki Inoue
Journal:  Nat Commun       Date:  2019-07-05       Impact factor: 14.919
  2 in total

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