Femke F Wilms1, Jolande Y Vis2, Martijn A Oudijk3, Anneke Kwee3, Martina M Porath1, Hubertina C J Scheepers4, Marc E A Spaanderman4, Kitty W M Bloemenkamp5, Antoinette C Bolte6, Caroline J Bax6, Jérôme M J Cornette7, Johannes J Duvekot7, Bas W A Nij Bijvanck8, Jim van Eijck8, Maureen T M Franssen9, Krystyna M Sollie9, Frank P H A Vandenbussche10, Mallory D Woiski10, Joris A M van der Post11, Patrick M M Bossuyt12, Brent C Opmeer12, Ben W J Mol13, Gert-Jan van Baaren11. 1. a Department of Obstetrics & Gynecology , Máxima Medical Center , Veldhoven , Netherlands . 2. b Department of Clinical Chemistry & Haematology , University Medical Center Utrecht , Utrecht , the Netherlands . 3. c Department of Obstetrics & Gynecology , University Medical Center Utrecht , Utrecht , Netherlands . 4. d Department of Obstetrics & Gynecology , Maastricht University Medical Center , Maastricht , Netherlands . 5. e Department of Obstetrics & Gynecology , Leiden University Medical Center , Leiden , Netherlands . 6. f Department of Obstetrics & Gynecology , VU University Medical Center , Amsterdam , Netherlands . 7. g Department of Obstetrics & Gynecology , Erasmus University Medical Center , Rotterdam , Netherlands . 8. h Department of Obstetrics & Gynecology , Isala Clinics , Zwolle , Netherlands . 9. i Department of Obstetrics & Gynecology , University Medical Center Groningen , Groningen , Netherlands . 10. j Department of Obstetrics & Gynecology , Radboud University Hospital Nijmegen , Nijmegen , Netherlands . 11. k Department of Obstetrics & Gynecology , Academic Medical Center , Amsterdam , Netherlands . 12. l Clinical Research Unit, Academic Medical Center , Amsterdam , Netherlands , and. 13. m The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide , Adelaide , Australia.
Abstract
OBJECTIVE: The objective of this study is to evaluate the relation among fetal gender, ethnicity, and preterm labor (PTL) and preterm delivery (PTD). METHODS: A secondary analysis was performed of a prospective cohort study including women with symptoms of PTL between 24 and 34 weeks. The proportion of women carrying a male or female fetus at the onset of PTL was calculated. Gestational age at delivery and risk of PTD of both fetal genders was compared and interaction of fetal gender and maternal ethnicity on the risk of PTD was evaluated. RESULTS: Of the 594 included women, 327 (55%) carried a male fetus. Median gestational age at delivery in women pregnant with a male fetus was 37 5/7 (IQR 34 4/7-39 1/7) weeks compared with 38 1/7 (IQR 36 0/7-39 5/7) weeks in women pregnant with a female fetus (p = 0.032). The risk of PTD did not differ significantly. In Caucasians, we did find an increased risk of PTD before 37 weeks in women pregnant with a male fetus (OR 1.9 (95% CI 1.2-3.0)). CONCLUSIONS: The majority of women with PTL are pregnant with a male fetus and these women deliver slightly earlier. Race seems to affect this disparity.
OBJECTIVE: The objective of this study is to evaluate the relation among fetal gender, ethnicity, and preterm labor (PTL) and preterm delivery (PTD). METHODS: A secondary analysis was performed of a prospective cohort study including women with symptoms of PTL between 24 and 34 weeks. The proportion of women carrying a male or female fetus at the onset of PTL was calculated. Gestational age at delivery and risk of PTD of both fetal genders was compared and interaction of fetal gender and maternal ethnicity on the risk of PTD was evaluated. RESULTS: Of the 594 included women, 327 (55%) carried a male fetus. Median gestational age at delivery in women pregnant with a male fetus was 37 5/7 (IQR 34 4/7-39 1/7) weeks compared with 38 1/7 (IQR 36 0/7-39 5/7) weeks in women pregnant with a female fetus (p = 0.032). The risk of PTD did not differ significantly. In Caucasians, we did find an increased risk of PTD before 37 weeks in women pregnant with a male fetus (OR 1.9 (95% CI 1.2-3.0)). CONCLUSIONS: The majority of women with PTL are pregnant with a male fetus and these women deliver slightly earlier. Race seems to affect this disparity.
Authors: Myrthe J C S Peelen; Brenda M Kazemier; Anita C J Ravelli; Christianne J M de Groot; Joris A M van der Post; Ben W J Mol; Marjolein Kok; Petra J Hajenius Journal: J Perinatol Date: 2021-03-09 Impact factor: 2.521
Authors: Sheila Lorente-Pozo; Anna Parra-Llorca; Begoña Torres; Isabel Torres-Cuevas; Antonio Nuñez-Ramiro; María Cernada; Ana García-Robles; Maximo Vento Journal: Front Pediatr Date: 2018-04-23 Impact factor: 3.418