Literature DB >> 26911403

Cyclopalladated organosilane-tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity.

Muneebah Adams1, Linley Barnard, Carmen de Kock, Peter J Smith, Lubbe Wiesner, Kelly Chibale, Gregory S Smith.   

Abstract

Two series of ferrocenyl- and aryl-derived cyclopalladated organosilane thiosemicarbazone complexes were synthesised via C-H bond activation. Selected compounds were evaluated for in vitro antiplasmodial activity against the chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) strains of the human malaria parasite Plasmodium falciparum. Cyclopalladation of the thiosemicarbazones resulted in antiplasmodial activities in the low micromolar range.

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Year:  2016        PMID： 26911403     DOI： 10.1039/c5dt04918k

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  5 in total

1.  Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions.

Authors:  Irwin Cassells; Tameryn Stringer; Alan T Hutton; Sharon Prince; Gregory S Smith
Journal:  J Biol Inorg Chem       Date:  2018-05-30       Impact factor: 3.358

2.  Theoretical analysis of the binding of iron(III) protoporphyrin IX to 4-methoxyacetophenone thiosemicarbazone via DFT-D3, MEP, QTAIM, NCI, ELF, and LOL studies.

Authors:  Nyiang Kennet Nkungli; Julius Numbonui Ghogomu
Journal:  J Mol Model       Date:  2017-06-09       Impact factor: 1.810

3.  Schiff bases of sulphonamides as a new class of antifungal agent against multidrug-resistant Candida auris.

Authors:  Asad Hamad; Yiyuan Chen; Mohsin A Khan; Shirin Jamshidi; Naima Saeed; Melanie Clifford; Charlotte Hind; J Mark Sutton; Khondaker Miraz Rahman
Journal:  Microbiologyopen       Date:  2021-08       Impact factor: 3.139

4.  Bio-oriented synthesis of new sulphadiazine derivatives for urease inhibition and their pharmacokinetic analysis.

Authors:  Asad Hamad; Mohsin Abbas Khan; Irshad Ahmad; Ruqaiya Khalil; Muhammad Khalid; Urva Abbas; Rahat Azhar; Jalal Uddin; Gaber El-Saber Batiha; Ajmal Khan; Zahid Shafiq; Ahmed Al-Harrasi
Journal:  Sci Rep       Date:  2021-09-23       Impact factor: 4.379

Review 5.  Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents.

Authors:  Mziyanda Mbaba; Taryn M Golding; Gregory S Smith
Journal:  Molecules       Date:  2020-11-12       Impact factor: 4.411
  5 in total

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