BACKGROUND: Some obese children do not show cardiometabolic complications such as prediabetes, dyslipidemia or insulin resistance. The objective of the study was to classify obese children and adolescents as metabolically "healthy" obese (MHO) on the basis of three different definitions, and to compare cardiometabolic features with metabolically unhealthy obese (MUO) children and adolescents. METHODS: The study included 156 obese children and adolescents aged between 10 and 18. Subjects were classified as MHO or MUO using three definitions based on the: (1) pediatric International Diabetes Federation (IDF) criteria; (2) homeostatic model assessment of insulin resistance (HOMA-IR); (3) combination of the previous two definitions. Cardiometabolic features were compared between MHO and MUO subjects. RESULTS: Six to 19% obese children and adolescents were classified as MHO, and showed a better insulin sensitivity, lower prevalence of prediabetes, lower triglycerides and lower triglyceride-to-HDL-C ratio compared to MUO. CONCLUSIONS: Less than 20% obese children and adolescents are identified as MHO and show a healthier cardiometabolic profile as compared to MUO. Implementation of the proposed classifications in future clinical research could contribute towards the standardization of the MHO definition and offer new insights into the manifestation of the pediatric MHO phenotype.
BACKGROUND: Some obesechildren do not show cardiometabolic complications such as prediabetes, dyslipidemia or insulin resistance. The objective of the study was to classify obesechildren and adolescents as metabolically "healthy" obese (MHO) on the basis of three different definitions, and to compare cardiometabolic features with metabolically unhealthy obese (MUO) children and adolescents. METHODS: The study included 156 obesechildren and adolescents aged between 10 and 18. Subjects were classified as MHO or MUO using three definitions based on the: (1) pediatric International Diabetes Federation (IDF) criteria; (2) homeostatic model assessment of insulin resistance (HOMA-IR); (3) combination of the previous two definitions. Cardiometabolic features were compared between MHO and MUO subjects. RESULTS: Six to 19% obesechildren and adolescents were classified as MHO, and showed a better insulin sensitivity, lower prevalence of prediabetes, lower triglycerides and lower triglyceride-to-HDL-C ratio compared to MUO. CONCLUSIONS: Less than 20% obesechildren and adolescents are identified as MHO and show a healthier cardiometabolic profile as compared to MUO. Implementation of the proposed classifications in future clinical research could contribute towards the standardization of the MHO definition and offer new insights into the manifestation of the pediatric MHO phenotype.
Authors: Jieyu Liu; Tao Ma; Manman Chen; Ying Ma; Yanhui Li; Di Gao; Qi Ma; Xinxin Wang; Li Chen; Yi Zhang; Yanhui Dong; Yi Song; Jun Ma Journal: Front Endocrinol (Lausanne) Date: 2022-08-25 Impact factor: 6.055
Authors: Abel Plaza-Florido; Signe Altmäe; Francisco J Esteban; Cristina Cadenas-Sanchez; Concepción M Aguilera; Elisabet Einarsdottir; Shintaro Katayama; Kaarel Krjutškov; Juha Kere; Frank Zaldivar; Shlomit Radom-Aizik; Francisco B Ortega Journal: Pediatr Res Date: 2020-11-23 Impact factor: 3.756