Shi-Sheng Zhou1, Yi-Ming Zhou2, Da Li3, Na-Na Chen4. 1. a Institute of Basic Medical Sciences , Medical College, Dalian University , Dalian , China. 2. b Renal Division, Department of Medicine , Brigham and Women's Hospital, Harvard Institutes of Medicine, Harvard Medical School , Boston , MA , USA. 3. c Department of Obstetrics and Gynecology , Shengjing Hospital of China Medical University , Shenyang , China. 4. d Department of Molecular Immunology , Graduate School of Medicine, Nagoya University , Nagoya , Japan.
Abstract
OBJECTIVE: To summarize the reported evidence on the relationship between vasoactive amines and preeclampsia. METHODS: A literature search was conducted in MEDLINE/PubMed and EMBASE. RESULTS: The summarized results are as follows: (1) Menstruation can effectively eliminate vasoactive amines norepinephrine, serotonin and histamine. (2) Pregnancy increases norepinephrine production due to fetal brain development and decreases vasoactive-amine elimination due to amenorrhea. (3) Preeclampsia is associated with a low renal and/or sweating capacity, or in rare cases, with increased norepinephrine production due to maternal pheochromocytoma and fetal neuroblastoma. CONCLUSION: Preeclampsia is mainly due to decreased excretion of norepinephrine and other vasoactive amines.
OBJECTIVE: To summarize the reported evidence on the relationship between vasoactive amines and preeclampsia. METHODS: A literature search was conducted in MEDLINE/PubMed and EMBASE. RESULTS: The summarized results are as follows: (1) Menstruation can effectively eliminate vasoactive aminesnorepinephrine, serotonin and histamine. (2) Pregnancy increases norepinephrine production due to fetal brain development and decreases vasoactive-amine elimination due to amenorrhea. (3) Preeclampsia is associated with a low renal and/or sweating capacity, or in rare cases, with increased norepinephrine production due to maternal pheochromocytoma and fetal neuroblastoma. CONCLUSION: Preeclampsia is mainly due to decreased excretion of norepinephrine and other vasoactive amines.
Authors: Dalia Yousif; Ioannis Bellos; Ana Isabel Penzlin; Mido Max Hijazi; Ben Min-Woo Illigens; Alexandra Pinter; Timo Siepmann Journal: Front Neurol Date: 2019-08-06 Impact factor: 4.003