Literature DB >> 26908724

Helicobacter pylori CagL Hypervariable Motif: A Global Analysis of Geographical Diversity and Association With Gastric Cancer.

Rebecca J Gorrell1, Nicolas Zwickel2, John Reynolds3, Dieter Bulach4, Terry Kwok1.   

Abstract

Previous studies suggest overrepresentation of particular polymorphisms within the Helicobacter pylori CagL hypervariable motif (CagLHM) in gastric cancer-associated isolates. However, these disease correlations were geographically variable and ambiguous. We compared the disease correlation of several hundred geographically diverse CagL sequences and identified 33 CagLHM sequence combinations with disparate geographical distribution, revealing substantial worldwide CagLHM diversity, particularly within Asian countries. Notably, polymorphisms E59 and I60 were significantly overrepresented, whereas D58 and E62 were underrepresented, in gastric cancer-associated H. pylori isolates worldwide. Thus, CagLHM regional diversity may contribute to the varied prevalence of H. pylori-related gastric cancer observed in diverse populations.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Entities:  

Keywords:  CagL; Helicobacter pylori; gastric cancer; gastritis; geographical diversity; host/pathogen co-evolution; host/pathogen interaction; integrin; peptic ulcer disease; sequence polymorphism

Mesh：

Substances：

Year:  2016        PMID： 26908724     DOI： 10.1093/infdis/jiw060

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  11 in total

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Authors:  Jay E Gordon; Tiago R D Costa; Roosheel S Patel; Christian Gonzalez-Rivera; Mayukh K Sarkar; Elena V Orlova; Gabriel Waksman; Peter J Christie
Journal:  Mol Microbiol       Date:  2017-05-18       Impact factor: 3.501

2.  Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains.

Authors:  Tobias Bönig; Patrick Olbermann; Simon H Bats; Wolfgang Fischer; Christine Josenhans
Journal:  Sci Rep       Date:  2016-12-06       Impact factor: 4.379

3.  Association between polymorphisms of thymidylate synthase gene 5'- and 3'-UTR and gastric cancer risk: meta-analysis.

Authors:  Ao Mo; Yongliang Zhao; Yan Shi; Feng Qian; Yingxue Hao; Jun Chen; Shiwei Yang; Yuxing Jiang; Ziyan Luo; Peiwu Yu
Journal:  Biosci Rep       Date:  2016-12-23       Impact factor: 3.840

4.  Whole Genome Sequence and Phylogenetic Analysis Show Helicobacter pylori Strains from Latin America Have Followed a Unique Evolution Pathway.

Authors:  Zilia Y Muñoz-Ramírez; Alfonso Mendez-Tenorio; Ikuko Kato; Maria M Bravo; Cosmeri Rizzato; Kaisa Thorell; Roberto Torres; Francisco Aviles-Jimenez; Margarita Camorlinga; Federico Canzian; Javier Torres
Journal:  Front Cell Infect Microbiol       Date:  2017-02-28       Impact factor: 5.293

5.  Distribution and clinical associations of integrating conjugative elements and cag pathogenicity islands of Helicobacter pylori in Indonesia.

Authors:  Langgeng Agung Waskito; Muhammad Miftahussurur; Maria Inge Lusida; Ari Fahrial Syam; Rumiko Suzuki; Phawinee Subsomwong; Tomohisa Uchida; Muhammad Hamdan; Yoshio Yamaoka
Journal:  Sci Rep       Date:  2018-04-17       Impact factor: 4.379

6.  Genetic diversity and amino acid sequence polymorphism in Helicobacter pylori CagL hypervariable motif and its association with virulence markers and gastroduodenal diseases.

Authors:  Abbas Yadegar; Ashraf Mohabati Mobarez; Mohammad Reza Zali
Journal:  Cancer Med       Date:  2019-03-14       Impact factor: 4.452

7.  Variations in cag pathogenicity island genes of Helicobacter pylori from Latin American groups may influence neoplastic progression to gastric cancer.

Authors:  Cosmeri Rizzato; Javier Torres; Ofure Obazee; Margarita Camorlinga-Ponce; Esperanza Trujillo; Angelika Stein; Alfonso Mendez-Tenorio; Maria Mercedes Bravo; Federico Canzian; Ikuko Kato
Journal:  Sci Rep       Date:  2020-04-16       Impact factor: 4.379

8.  Efficacy of Helicobacter pylori eradication regimens in Rwanda: a randomized controlled trial.

Authors:  Jean Damascene Kabakambira; Celestin Hategeka; Cameron Page; Cyprien Ntirenganya; Vincent Dusabejambo; Jules Ndoli; Francois Ngabonziza; DeVon Hale; Claude Bayingana; Tim Walker
Journal:  BMC Gastroenterol       Date:  2018-08-30       Impact factor: 3.067

9.  CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.

Authors:  Adolfo Román-Román; Verónica I Martínez-Santos; Carlos A Castañón-Sánchez; Alan J Albañil-Muñoz; Paola González-Mendoza; Diana G Soto-Flores; Dinorah N Martínez-Carrillo; Gloria Fernández-Tilapa
Journal:  Gut Pathog       Date:  2019-02-13       Impact factor: 4.181

Review 10.  Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity.

Authors:  Shamshul Ansari; Yoshio Yamaoka
Journal:  Toxins (Basel)       Date:  2019-11-19       Impact factor: 4.546
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