Axel Kloppe1, Thomas Lawo2, Dejan Mijic3, Fabian Schiedat2, Andreas Muegge2, Bernd Lemke3. 1. Dept of Cardiology and Angiology, Klinikum Bergmannsheil, Ruhr University Bochum, Germany. Electronic address: kloppe@web.de. 2. Dept of Cardiology and Angiology, Klinikum Bergmannsheil, Ruhr University Bochum, Germany. 3. Dept of Cardiology and Angiology, Klinikum Luedenscheid, Luedenscheid, Germany.
Abstract
AIMS: Cardiac Contractility Modulation (CCM) is a treatment for heart failure based on electrical signals applied during the absolute refractory period. CCM improves myocardial molecular and biochemical characteristics of heart failure and improves exercise tolerance and quality of life. However, the long term impact on survival has not been described. METHODS AND RESULTS: Survival was determined retrospectively from a cohort of 68 consecutive heart failure cases with NYHA II or III symptoms and QRS duration ≤130ms, implanted with a CCM device between May 2002 and July 2013 in either Bochum or Ludenscheid, Germany. Results were compared with predicted survival (Seattle Heart Failure Model; SHFM) pre-implant for each patient. Mean follow-up was 4.5years (range 0.25-10.3years). Baseline characteristics were as follows: mean age 61years, 88% male, 68% with ischemic heart disease, 78% with an ICD, mean NYHA class 2.9±0.3, LVEF 26%±6% (range 15-40%) and mean QRS duration 106±11ms. Mortality rates (Kaplan-Meier analysis) at 1-, 2- and 5-years were lower with CCM than predicted by SHFM for the cohort (0% with CCM vs. 6.1% per SHFM, 3.5% vs. 11.8%, and 14.2% vs. 27.7%, respectively, p=0.007). CONCLUSIONS: Long-term mortality rates in heart failure patients with NYHA (II-III) and QRS≤130ms are lower when treated by CCM than predicted for the cohort. These findings warrant substantiation in a prospective study.
AIMS: Cardiac Contractility Modulation (CCM) is a treatment for heart failure based on electrical signals applied during the absolute refractory period. CCM improves myocardial molecular and biochemical characteristics of heart failure and improves exercise tolerance and quality of life. However, the long term impact on survival has not been described. METHODS AND RESULTS: Survival was determined retrospectively from a cohort of 68 consecutive heart failure cases with NYHA II or III symptoms and QRS duration ≤130ms, implanted with a CCM device between May 2002 and July 2013 in either Bochum or Ludenscheid, Germany. Results were compared with predicted survival (Seattle Heart Failure Model; SHFM) pre-implant for each patient. Mean follow-up was 4.5years (range 0.25-10.3years). Baseline characteristics were as follows: mean age 61years, 88% male, 68% with ischemic heart disease, 78% with an ICD, mean NYHA class 2.9±0.3, LVEF 26%±6% (range 15-40%) and mean QRS duration 106±11ms. Mortality rates (Kaplan-Meier analysis) at 1-, 2- and 5-years were lower with CCM than predicted by SHFM for the cohort (0% with CCM vs. 6.1% per SHFM, 3.5% vs. 11.8%, and 14.2% vs. 27.7%, respectively, p=0.007). CONCLUSIONS: Long-term mortality rates in heart failurepatients with NYHA (II-III) and QRS≤130ms are lower when treated by CCM than predicted for the cohort. These findings warrant substantiation in a prospective study.
Authors: D Müller; A Remppis; P Schauerte; S Schmidt-Schweda; D Burkhoff; B Rousso; D Gutterman; J Senges; G Hindricks; K-H Kuck Journal: Clin Res Cardiol Date: 2017-07-06 Impact factor: 5.460
Authors: Daniele Masarone; Andrea Petraio; Antonio Fiorentino; Santo Dellegrottaglie; Fabio Valente; Ernesto Ammendola; Gerardo Nigro; Giuseppe Pacileo Journal: Front Cardiovasc Med Date: 2022-02-16