Literature DB >> 2690821

Development of insulin sensitivity in white adipose tissue during the suckling-weaning transition in the rat. Involvement of glucose transport and lipogenesis.

T Issad1, P Ferré, M Pastor-Anglada, M A Baudon, J Girard.   

Abstract

The changes of insulin responsiveness of white adipose tissue during the suckling-weaning transition in the rat were investigated in vitro on isolated adipocytes. Insulin binding, glucose transport and glucose metabolism in adipocytes from suckling rats and from rats weaned on to a high-carbohydrate (HC) or a high-fat (HF) diet were compared. Despite similar insulin binding, insulin-stimulated glucose transport rate is lower in adipocytes from suckling rats and HF-weaned rats than in adipocytes from HC-weaned rats. Moreover, whereas insulin markedly stimulates glucose metabolism in adipocytes from HC-weaned rats, glucose metabolism is totally unresponsive to insulin in adipocytes from suckling and HF-weaned rats. This insulin resistance is associated with a very low rate of lipogenesis and low activities of acetyl-CoA carboxylase, fatty acid synthase and pyruvate dehydrogenase.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2690821      PMCID： PMC1133566          DOI： 10.1042/bj2640217

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  38 in total

1.  Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats.

Authors:  D Stansbie; R W Brownsey; M Crettaz; R M Denton
Journal:  Biochem J       Date:  1976-11-15       Impact factor: 3.857

2.  A reliable photomicrographic method to determining fat cell size and number: application to dietary obesity.

Authors:  M Lavau; C Susini; J Knittle; S Blanchet-Hirst; M R Greenwood
Journal:  Proc Soc Exp Biol Med       Date:  1977-11

Review 3.  Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones.

Authors:  P J Randle; A L Kerbey; J Espinal
Journal:  Diabetes Metab Rev       Date:  1988-11

4.  The effect of diet fat on rat adipocyte glucose transport.

Authors:  C Ip; H M Tepperman; J De Witt; J Tepperman
Journal:  Horm Metab Res       Date:  1977-05       Impact factor: 2.936

5.  Binding and degradation of 125I-labelled insulin by isolated rat fat cells.

Authors:  S Gammeltoft; J Gliemann
Journal:  Biochim Biophys Acta       Date:  1973-08-17

6.  Influence of exogenous fat and gluconeogenic substrates on glucose homeostasis in the newborn rat.

Authors:  P Ferré; J P Pegorier; E B Marliss; J R Girard
Journal:  Am J Physiol       Date:  1978-02

7.  Changes in diet and patterns of feeding activity of developing rats.

Authors:  R S Redman; L R Sweney
Journal:  J Nutr       Date:  1976-05       Impact factor: 4.798

8.  Effect of experimental hyperinsulinaemia on intracellular glucose metabolism of isolated adipocytes.

Authors:  M Kobayashi; J M Olefsky
Journal:  Diabetologia       Date:  1979-08       Impact factor: 10.122

9.  The effects of dietary carbohydrate content on insulin binding and glucose metabolism by isolated rat adipocytes.

Authors:  J M Olefsky; M Saekow
Journal:  Endocrinology       Date:  1978-12       Impact factor: 4.736

10.  Primary role of decreased fatty acid synthesis in insulin resistance of large rat adipocytes.

Authors:  D K Richardson; M P Czech
Journal:  Am J Physiol       Date:  1978-02
View more
  5 in total

1.  A new highly efficient substrate-trapping mutant of protein tyrosine phosphatase 1B (PTP1B) reveals full autoactivation of the insulin receptor precursor.

Authors:  Samira Boubekeur; Nicolas Boute; Patrick Pagesy; Vladimir Zilberfarb; Névéna Christeff; Tarik Issad
Journal:  J Biol Chem       Date:  2011-04-12       Impact factor: 5.157

2.  Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations.

Authors:  F Mourrieras; F Foufelle; M Foretz; J Morin; S Bouche; P Ferre
Journal:  Biochem J       Date:  1997-09-01       Impact factor: 3.857

3.  Increased gene expression of lipogenic enzymes and glucose transporter in white adipose tissue of suckling and weaned obese Zucker rats.

Authors:  L Pénicaud; P Ferré; F Assimacopoulos-Jeannet; D Perdereau; A Leturque; B Jeanrenaud; L Picon; J Girard
Journal:  Biochem J       Date:  1991-10-01       Impact factor: 3.857

4.  Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat.

Authors:  J Maury; A L Kerbey; D A Priestman; M S Patel; J Girard; P Ferre
Journal:  Biochem J       Date:  1995-10-15       Impact factor: 3.857

5.  Protein O-GlcNAcylation levels are regulated independently of dietary intake in a tissue and time-specific manner during rat postnatal development.

Authors:  Thomas Dupas; Manon Denis; Justine Dontaine; Antoine Persello; Laurent Bultot; Angélique Erraud; Didier Vertommen; Bertrand Bouchard; Arnaud Tessier; Matthieu Rivière; Jacques Lebreton; Edith Bigot-Corbel; Jérôme Montnach; Michel De Waard; Chantal Gauthier; Yan Burelle; Aaron K Olson; Bertrand Rozec; Christine Des Rosiers; Luc Bertrand; Tarik Issad; Benjamin Lauzier
Journal:  Acta Physiol (Oxf)       Date:  2020-10-16       Impact factor: 6.311
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.