R Bakir1, A-L Lecapitaine2, J Chevalier2, B Juberthie3, M-A Bouldouyre2, H Gros2. 1. Service de médecine interne et de maladies infectieuses, centre hospitalier Robert-Ballanger, 1, boulevard Robert-Ballanger, 93602 Aulnay-sous-Bois cedex, France. Electronic address: redouane.bakir@ch-aulnay.fr. 2. Service de médecine interne et de maladies infectieuses, centre hospitalier Robert-Ballanger, 1, boulevard Robert-Ballanger, 93602 Aulnay-sous-Bois cedex, France. 3. Service d'anatomie pathologique, centre hospitalier Robert-Ballanger, 1, boulevard Robert-Ballanger, 93602 Aulnay-sous-Bois cedex, France.
Abstract
INTRODUCTION: The histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto's disease is characterized by a lymph node inflammation whose similarity with systemic lupus is generally admitted. CASE REPORT: Our description of two familial cases aims at raising the hypothesis of the existence of a genetic background in this disease following the example of what is observed in the autoimmune diseases. CONCLUSION: Pathophysiology of Kikuchi-Fujimoto's disease is probably multifactorial and may include predisposing genetic background and a possible infectious triggering event.
INTRODUCTION: The histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto's disease is characterized by a lymph node inflammation whose similarity with systemic lupus is generally admitted. CASE REPORT: Our description of two familial cases aims at raising the hypothesis of the existence of a genetic background in this disease following the example of what is observed in the autoimmune diseases. CONCLUSION: Pathophysiology of Kikuchi-Fujimoto's disease is probably multifactorial and may include predisposing genetic background and a possible infectious triggering event.
Authors: Rahim A Jiwani; Daniel N Jourdan; Adrian Pona; Deepak Donthi; J Stephen Stalls; Rita W Rehana Journal: J Community Hosp Intern Med Perspect Date: 2021-01-26