Literature DB >> 26906216

Exploiting Copper Redox for (19)F Magnetic Resonance-Based Detection of Cellular Hypoxia.

Da Xie1, Tyler L King1, Arnab Banerjee1, Vikraant Kohli1, Emily L Que1.   

Abstract

We report a pair of fluorinated, redox-active copper complexes for potential use as (19)F MRI contrast agents for detecting cellular hypoxia. Trifluorinated Cu(II) ATSM-F3 displays the appropriate redox potential for selective accumulation in hypoxic cells and a completely quenched (19)F NMR signal that is "turned on" following reduction to Cu(I). Incubation of cancer cells with CuATSM-F3 resulted in a selective detection of (19)F signal in cells grown under hypoxic conditions.

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Year:  2016        PMID： 26906216     DOI： 10.1021/jacs.5b13215

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  11 in total

1.  Physical properties, ligand substitution reactions, and biological activity of Co(iii)-Schiff base complexes.

Authors:  A Paden King; Hendryck A Gellineau; Samantha N MacMillan; Justin J Wilson
Journal:  Dalton Trans       Date:  2019-05-07       Impact factor: 4.390

Review 2.  Copper-Promoted Functionalization of Organic Molecules: from Biologically Relevant Cu/O2 Model Systems to Organometallic Transformations.

Authors:  Rachel Trammell; Khashayar Rajabimoghadam; Isaac Garcia-Bosch
Journal:  Chem Rev       Date:  2019-01-30       Impact factor: 60.622

3.  Intracellular redox potential is correlated with miRNA expression in MCF7 cells under hypoxic conditions.

Authors:  Hannah Johnston; Paul Dickinson; Alasdair Ivens; Amy H Buck; R D Levine; Francoise Remacle; Colin J Campbell
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-10       Impact factor: 11.205

4.  Copper(ii) complexes for cysteine detection using 19F magnetic resonance.

Authors:  José S Enriquez; Meng Yu; Bailey S Bouley; Da Xie; Emily L Que
Journal:  Dalton Trans       Date:  2018-10-30       Impact factor: 4.390

Review 5.  Fluorinated Paramagnetic Complexes: Sensitive and Responsive Probes for Magnetic Resonance Spectroscopy and Imaging.

Authors:  Katie L Peterson; Kriti Srivastava; Valérie C Pierre
Journal:  Front Chem       Date:  2018-05-23       Impact factor: 5.221

6.  Fluorinated EuII-based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging.

Authors:  Lina A Basal; Matthew D Bailey; Jonathan Romero; Meser M Ali; Lyazat Kurenbekova; Jason Yustein; Robia G Pautler; Matthew J Allen
Journal:  Chem Sci       Date:  2017-10-26       Impact factor: 9.825

7.  Rational Design of High-Relaxivity EuII -Based Contrast Agents for Magnetic Resonance Imaging of Low-Oxygen Environments.

Authors:  Matthew D Bailey; Guo-Xia Jin; Fabio Carniato; Mauro Botta; Matthew J Allen
Journal:  Chemistry       Date:  2021-01-14       Impact factor: 5.236

Review 8.  Perfluorocarbons in Chemical Biology.

Authors:  Margeaux A Miller; Ellen M Sletten
Journal:  Chembiochem       Date:  2020-08-05       Impact factor: 3.164

9.  Antibacterial Thiamine inspired silver (I) and gold (I) N-heterocyclic carbene compounds.

Authors:  Orhi Esarte Palomero; Ashley L Cunningham; Bryan W Davies; Richard A Jones
Journal:  Inorganica Chim Acta       Date:  2020-11-27       Impact factor: 2.545

10.  Ratiometric quantitation of redox status with a molecular Fe2 magnetic resonance probe.

Authors:  Kang Du; Emily A Waters; T David Harris
Journal:  Chem Sci       Date:  2017-04-19       Impact factor: 9.825
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