Souad Kotbi1, Amal Mjabber2, Asma Chadli3, Ayoub El Hammiri4, Siham El Aziz2, Bouchra Oukkache5, Hassan Mifdal6, Nadia Nourichafi6, Nabiha Kamal7, Rachida Habbal4, Norredine Ghalim8, Ahmed Farouqi2, Mostafa Kabine1. 1. Department of Biology, Laboratory of Biochemistry and Molecular Biology, Ain chock Faculty of Science, Km 9, El Jadida road, Box 5366 Maarif, Casablanca, Morocco. 2. Endocrinology and Metabolic Diseases department, Ibn Rochd, University Hospital Center 1, Hospitals part, Casablanca, Morocco. 3. Endocrinology and Metabolic Diseases department, Ibn Rochd, University Hospital Center 1, Hospitals part, Casablanca, Morocco. Electronic address: drachadli@gmail.com. 4. Cardiology department, Ibn Rochd university, Hospital Center, 1, Hospitals part, Casablanca, Morocco. 5. Regional blood transfusion centre, 1, Mohamed El Fidouzi-ex Jenner street, Casablanca, Morocco. 6. Hematology laboratory, Ibn Rochd university, Hospital Center, Hospitals part, Casablanca, Morocco. 7. Laboratory of biochemistry, Ibn Rochd university, Hospital Center, 1, Hospitals part, Casablanca, Morocco. 8. Department of medical biology, Pasteur Institute of Morocco, 1, place Louis-Pasteur, 20360 Casablanca, Morocco.
Abstract
AIM: The present study aims at determining the relationship between the plasma fibrinogen concentration and the severity of coronary heart disease in type 2 diabetic patients. METHODS: Prospective analytical survey, based on a sample of 120 subjects divided in four groups: 30 non diabetic coronary patients (G1), 30 coronary diabetic patients (G2), 30 non-coronary diabetic patients (G3), and 30 healthy subjects (G4). RESULTS: The average age was 59.58±7.88 years; female gender predominated by 52.5%. The plasma fibrinogen concentration corresponded to 3.46g/L±0.86 in G1; 3.73g/L±1.11 in G2; 3.06g/L±0.98 in G3 and 2.46g/L±0.51 in G4; with a significant difference between the four groups (P=0.001). The plasma fibrinogen concentration increased in parallel with the cardiovascular risk (P=0.0001); there was also a significant correlation between the plasma fibrinogen concentration and the clinical and para-clinical coronary disease severity (respectively P=0.005 and P=0.0001). A positive correlation between the plasma fibrinogen concentration and hyperglycemia (P=0.035) was found in G4. But no correlation with the lipids parameters, except for the low density-lipoproteins in G3 (P=0.035). CONCLUSION: In the Moroccan population, the plasma fibrinogen concentration was positively and significantly correlated with the coronary heart disease severity.
AIM: The present study aims at determining the relationship between the plasma fibrinogen concentration and the severity of coronary heart disease in type 2 diabeticpatients. METHODS: Prospective analytical survey, based on a sample of 120 subjects divided in four groups: 30 non diabetic coronary patients (G1), 30 coronary diabeticpatients (G2), 30 non-coronary diabeticpatients (G3), and 30 healthy subjects (G4). RESULTS: The average age was 59.58±7.88 years; female gender predominated by 52.5%. The plasma fibrinogen concentration corresponded to 3.46g/L±0.86 in G1; 3.73g/L±1.11 in G2; 3.06g/L±0.98 in G3 and 2.46g/L±0.51 in G4; with a significant difference between the four groups (P=0.001). The plasma fibrinogen concentration increased in parallel with the cardiovascular risk (P=0.0001); there was also a significant correlation between the plasma fibrinogen concentration and the clinical and para-clinical coronary disease severity (respectively P=0.005 and P=0.0001). A positive correlation between the plasma fibrinogen concentration and hyperglycemia (P=0.035) was found in G4. But no correlation with the lipids parameters, except for the low density-lipoproteins in G3 (P=0.035). CONCLUSION: In the Moroccan population, the plasma fibrinogen concentration was positively and significantly correlated with the coronary heart disease severity.