Feng-Di Liu1, Xiao-Lei Shen1, Rong Zhao1, Xiao-Xiao Tao1, Shuo Wang1, Jia-Jun Zhou2, Bo Zheng1, Qi-Ting Zhang1, Qian Yao1, Ying Zhao1, Xin Zhang1, Xue-Mei Wang1, Hui-Qin Liu3, Liang Shu4, Jian-Ren Liu5. 1. Department of Neurology, Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Huangpu District, Shanghai, 200011, China. 2. Department of Neurology, Xixi Hospital of Hangzhou, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310023, China. 3. Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, China. bingming6912@163.com. 4. Department of Neurology, Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Huangpu District, Shanghai, 200011, China. shuliang_9@hotmail.com. 5. Department of Neurology, Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Huangpu District, Shanghai, 200011, China. liujr021@163.com.
Abstract
BACKGROUND: Recent evidence suggests that pulse pressure (PP) is a strong cardiovascular diseases' risk factor. We systematically evaluated all relevant studies to determine whether PP can be used as an independent predictor of stroke and mortality. METHODS AND RESULTS: A meta-analysis was performed by searching the published literature using MEDLINE, Cochrane and Google Scholar databases up to December 15, 2015. We measured the effect size expressed by hazard ratio (HR) and 95 % confidence interval (95 % CI). Eleven publications were included in the analysis. Pooled results demonstrated that 10 mmHg increase in PP was associated with increased risk of stroke occurrence (pooled HR 1.046, 95 % CI 1.025-1.068, P < 0.001). Additionally, systolic blood pressure (SBP) (pooled HR 1.053, 95 % CI 1.033-1.073, P < 0.001) and diastolic blood pressure (DPB) (pooled HR 1.056, 95 % CI 1.038-1.074, P < 0.001) were found to be significant predictors for stroke. We did not find a significant association between PP and all-cause mortality (pooled HR 1.022, 95 % CI 0.983-1.063, P = 0.270). We found SBP (pooled HR 1.008, 95 % CI 1.002-1.014, P = 0.012), but not DBP (pooled HR 1.023, 95 % CI 0.964-1.085, P = 0.451) to be significantly associated with all-cause mortality. CONCLUSIONS: Current data confirms that PP is an independent risk factor for stroke but is not a predictor of mortality.
BACKGROUND: Recent evidence suggests that pulse pressure (PP) is a strong cardiovascular diseases' risk factor. We systematically evaluated all relevant studies to determine whether PP can be used as an independent predictor of stroke and mortality. METHODS AND RESULTS: A meta-analysis was performed by searching the published literature using MEDLINE, Cochrane and Google Scholar databases up to December 15, 2015. We measured the effect size expressed by hazard ratio (HR) and 95 % confidence interval (95 % CI). Eleven publications were included in the analysis. Pooled results demonstrated that 10 mmHg increase in PP was associated with increased risk of stroke occurrence (pooled HR 1.046, 95 % CI 1.025-1.068, P < 0.001). Additionally, systolic blood pressure (SBP) (pooled HR 1.053, 95 % CI 1.033-1.073, P < 0.001) and diastolic blood pressure (DPB) (pooled HR 1.056, 95 % CI 1.038-1.074, P < 0.001) were found to be significant predictors for stroke. We did not find a significant association between PP and all-cause mortality (pooled HR 1.022, 95 % CI 0.983-1.063, P = 0.270). We found SBP (pooled HR 1.008, 95 % CI 1.002-1.014, P = 0.012), but not DBP (pooled HR 1.023, 95 % CI 0.964-1.085, P = 0.451) to be significantly associated with all-cause mortality. CONCLUSIONS: Current data confirms that PP is an independent risk factor for stroke but is not a predictor of mortality.
Entities:
Keywords:
Predictor of mortality; Pulse pressure; Risk factor; Stroke
Authors: Jerzy Gasowski; Robert H Fagard; Jan A Staessen; Tomasz Grodzicki; Stuart Pocock; Florent Boutitie; François Gueyffier; Jean-Pierre Boissel Journal: J Hypertens Date: 2002-01 Impact factor: 4.844
Authors: J A Staessen; J Gasowski; J G Wang; L Thijs; E Den Hond; J P Boissel; J Coope; T Ekbom; F Gueyffier; L Liu; K Kerlikowske; S Pocock; R H Fagard Journal: Lancet Date: 2000-03-11 Impact factor: 79.321
Authors: B M Psaty; C D Furberg; L H Kuller; M Cushman; P J Savage; D Levine; D H O'Leary; R N Bryan; M Anderson; T Lumley Journal: Arch Intern Med Date: 2001-05-14
Authors: V Vaccarino; A K Berger; J Abramson; H R Black; J F Setaro; J A Davey; H M Krumholz Journal: Am J Cardiol Date: 2001-11-01 Impact factor: 2.778
Authors: G A J C Crombag; M Aizaz; F H B M Schreuder; F Benali; D H K van Dam-Nolen; M I Liem; C Lucci; A F van der Steen; M J A P Daemen; W H Mess; A van der Lugt; P J Nederkoorn; J Hendrikse; P A M Hofman; R J van Oostenbrugge; J E Wildberger; M E Kooi Journal: AJNR Am J Neuroradiol Date: 2022-02 Impact factor: 3.825