Literature DB >> 2690183

Chemistry and biological activity of antifolates.

A Rosowsky.   

Abstract

Mesh：

Substances：

Year:  1989        PMID： 2690183     DOI： 10.1016/s0079-6468(08)70241-8

Source DB:  PubMed          Journal:  Prog Med Chem        ISSN： 0079-6468


× No keyword cloud information.
  13 in total

1.  Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates.

Authors:  Aleem Gangjee; Yibin Qiu; Wei Li; Roy L Kisliuk
Journal:  J Med Chem       Date:  2008-09-25       Impact factor: 7.446

2.  Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.

Authors:  Aleem Gangjee; Jie Yang; John J McGuire; Roy L Kisliuk
Journal:  Bioorg Med Chem       Date:  2006-09-20       Impact factor: 3.641

3.  Isolation of rat dihydrofolate reductase gene and characterization of recombinant enzyme.

Authors:  Y Wang; J A Bruenn; S F Queener; V Cody
Journal:  Antimicrob Agents Chemother       Date:  2001-09       Impact factor: 5.191

4.  Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability.

Authors:  Yan Feng; James K Coward
Journal:  J Med Chem       Date:  2006-01-26       Impact factor: 7.446

5.  Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).

Authors:  Aleem Gangjee; Hiteshkumar D Jain; Jaclyn Phan; Xin Lin; Xiaohong Song; John J McGuire; Roy L Kisliuk
Journal:  J Med Chem       Date:  2006-02-09       Impact factor: 7.446

6.  Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.

Authors:  Aleem Gangjee; Yibin Zeng; John J McGuire; Roy L Kisliuk
Journal:  J Med Chem       Date:  2005-08-11       Impact factor: 7.446

7.  2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.

Authors:  Aleem Gangjee; Hiteshkumar D Jain; Jaclyn Phan; Xin Guo; Sherry F Queener; Roy L Kisliuk
Journal:  Bioorg Med Chem       Date:  2009-12-26       Impact factor: 3.641

8.  Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.

Authors:  Aleem Gangjee; Wei Li; Roy L Kisliuk; Vivian Cody; Jim Pace; Jennifer Piraino; Jennifer Makin
Journal:  J Med Chem       Date:  2009-08-13       Impact factor: 7.446

9.  Antifolates can potentiate topoisomerase II inhibitors in vitro and in vivo.

Authors:  S A Holden; B A Teicher; M F Robinson; D Northey; A Rosowsky
Journal:  Cancer Chemother Pharmacol       Date:  1995       Impact factor: 3.333

10.  Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.

Authors:  Aleem Gangjee; Yibin Zeng; Tina Talreja; John J McGuire; Roy L Kisliuk; Sherry F Queener
Journal:  J Med Chem       Date:  2007-06-07       Impact factor: 7.446
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.