| Literature DB >> 26900877 |
Guoyong Luo1,2,3, Qi Ye1, Baowen Du1, Fei Wang1, Guo-Lin Zhang1, Yinggang Luo1.
Abstract
Five new iridoid glucoside derivatives (1-5), three new diterpenoids (7, 12, and 15), and 11 known compounds were isolated from the aqueous EtOH extract of Caryopteris glutinosa. Cell-based estrogen biosynthesis assays indicated that caryopteriside C (3) and caryopterisoid B (12) promote the biosynthesis of estrogen E2, with EC50 values of 11.1 and 8.0 μM, respectively, in human ovarian granulosa-like KGN cells via upregulating the expression of aromatase.Entities:
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Year: 2016 PMID： 26900877 DOI： 10.1021/acs.jnatprod.5b00946
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050