Antonio Lacquaniti1, Chiara Caccamo2, Paola Salis2, Valeria Chirico3, Antoine Buemi4, Valeria Cernaro1, Alberto Noto5, Giuseppina Pettinato1, Domenico Santoro1, Tullio Bertani1, Michele Buemi1, Antonio David5. 1. a Department of Internal Medicine , University Hospital of Messina , Messina , Italy . 2. b Department of Internal Medicine , Mediterranean Institute for Transplantation and Advanced Specialized Therapies, ISMETT, University of Pittsburgh Medical Center , Palermo , Italy . 3. c Department of Pediatric Science , University Hospital of Messina , Messina , Italy . 4. d Surgery and Abdominal Transplantation Division, Cliniques Universitaires Saint-Luc, Université Catholique De Louvain , Brussels , Belgium , and. 5. e Department of Neuroscience , University Hospital of Messina , Messina , Italy.
Abstract
CONTEXT: Available markers are not reliable parameters to early detect kidney injury in transplanted patients. OBJECTIVE: Examine neutrophil gelatinase associated lipocalin (NGAL) in early detection of delayed graft function (DGF) and as a long-term predictor of graft outcome. PATIENTS AND METHODS: NGAL was evaluated in 124 transplanted patients. RESULTS: Urinary NGAL levels were associated to a 10% (HR: 1.10; 95% CI: 1.04-1.25; p < 0.001) and 15% (HR: 1.15; 95% CI: 1.09-1.26; p < 0.001) increased risk of DGF and allograft nephropathy progression, respectively. CONCLUSION: NGAL reflects the entity of renal impairment in transplanted patients, representing a biomarker and an independent risk factor for DGF and chronic allograft nephropathy progression.
CONTEXT: Available markers are not reliable parameters to early detect kidney injury in transplanted patients. OBJECTIVE: Examine neutrophil gelatinase associated lipocalin (NGAL) in early detection of delayed graft function (DGF) and as a long-term predictor of graft outcome. PATIENTS AND METHODS: NGAL was evaluated in 124 transplanted patients. RESULTS: Urinary NGAL levels were associated to a 10% (HR: 1.10; 95% CI: 1.04-1.25; p < 0.001) and 15% (HR: 1.15; 95% CI: 1.09-1.26; p < 0.001) increased risk of DGF and allograft nephropathy progression, respectively. CONCLUSION:NGAL reflects the entity of renal impairment in transplanted patients, representing a biomarker and an independent risk factor for DGF and chronic allograft nephropathy progression.
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