Use of the SMAS flap for reconstruction of the parotid lodge.

The purpose of our study was to evaluate the benefits of the SMAS flap in patients with benign tumours of the parotid gland treated by superficial parotidectomy. We carried out a retrospective chart review on 123 patients suffering from benign tumours of the parotid gland admitted to our Institution between March 1997 and March 2010. A superficial parotidectomy was performed in all the cases reported. Our sample was divided in two groups basing SMAS flap reconstruction done (Group 2) or not (Group 1) after superficial parotidectomy. Reconstruction using SMAS flap was accomplished in 64 patients. Chi-square test was used to assess statistical difference between the two groups. The level of statistical significance was P < 0.05. No significant differences concerning hematoma, wound infection and facial paralysis were observed between the first and second group (3.38 vs 1.56% [P > 0.05], 8.47% vs 4.68% [P > 0.05], 5.08% vs 0.00% [P > 0.05]). Transient facial nerve weakness, fistula, dip skin and Frey's syndrome were significantly more frequent without SMAS flap reconstruction (10.16% vs 3.125% [P < 0.05], 13.55% vs 3.125% [P < 0.05], 13.55% vs 3.125% [P < 0.05], 20.33% vs 0% [P < 0.05] respectively). The use of the SMAS flap is able to reduce the cosmetic and functional complications that occur after the removal of a benign tumour of the parotid through the superficial parotidectomy technique, above all, it reduces the occurrence of Frey's syndrome.

Introduction

Benign tumours of the parotid gland account for 70% of all salivary glands tumours . The literature shows that usually about 8 out of 10 salivary gland tumours are benign. The treatment of choice in the case of benign parotid tumours with a diameter greater than 3 cm located in the superficial portion of the parotid gland is superficial parotidectomy . This technique is also used in the case of tumour recurrence because it allows maintaining safety margins. Superficial parotidectomy is not free from complications; we report depression of the skin, salivary fistula, transient or persistent facial nerve paralysis, capsular rupture and Frey's syndrome -. Frey syndrome or auriculotemporal nerve syndrome was described for the first time by Lucy Frey in 1923 and is characterised by the appearance of redness, pain, sweating and heat in the parotid region following by gustatory stimulus. It is caused by an aberrant regeneration of injured postganglionic secretomotory parasympathetic nerve fibres of the auriculotemporal nerve after parotidectomy . Thanks to the face-lift incision introduced by Appiani and Delfino (1984) and the use of superficial muscoloaponeurotic system (SMAS) flap introduced by Rapaport and Allison in 1985 , there has been reduction of cosmetic and functional post-parotidectomy complications . The SMAS flap is a biological barrier capable of filling the cavity that is formed after removal of the tumour. The withdrawal of the SMAS flap is contextual to parotidectomy and increases surgical times very little (about 15 min) . The aim of our study was to compare postoperative outcomes after superficial parotidectomy in patients who receive or not parotid lodge reconstruction with SMAS flap.

Materials and methods

We carried out a retrospective chart review of 123 patients suffering from benign tumours of the parotid gland admitted to our Institution between March 1997 and March 2010. Patients had to meet the following inclusion criteria:

diagnosis of benign parotid tumour (pleomorphic adenoma or cystadenolymphoma);

indication for superficial parotidectomy;

possible reconstruction with SMAS flap;

modified face-lift incision.

Our cohort was divided in two groups:

Group 1 = 59 patients treated with superficial parotidectomy. In these cases, no flap reconstruction of the parotid lodge was used;

Group 2 = 64 patients treated with superficial parotidectomy and reconstructed with SMAS flap.

The decision of whether to use a SMAS flap or not was made individually by the surgeon who operated on each patient.

All patients underwent pre-operative diagnosis of parotid disease through colour Doppler ultrasonography, magnetic resonance or contrast-enhanced computed tomography, and fine needle aspiration cytology (FNAC) .

Patients had a minimum follow-up of 48 months and maximum of 120 months; mean of 84 months. All patients were screened for scarring and facial nerve functionality (Fig. 1). We also verified the presence of Frey's syndrome using the minor starch iodine test . One month after surgery each patient was administered a questionnaire to measure the degree of postoperative satisfaction on a visual analogue scale from 1 to 10. Values ranges from 1 to 3 showed a poor result, from 4 to 7 a good result and from 8 to 10 an excellent result.

Fig. 1.

(a) Pre-operative axial CT scan showing a left parotid lesion; (b) pre-operative patient appearance showing swelling on the left parotid region; (c) scar at 6 months follow-up.

Statistical calculations were performed with the Statistical Package for Social Sciences (version 17.0; SPSS, Chicago, IL). The difference between groups regarding evaluated recurrence rate and complications was measured with a χ2 test. The level of statistical significance was P < 0.05.

SMAS flap

The SMAS is a layer of muscle fibre and connective tissue located just under the skin and over the parotid fascia. Its function is to transmit, distribute and amplify the activity of all facial muscles .

The SMAS continues anteriorly in the mid-cheek area with the zygomatic muscles; above with the temporoparietal fascia and below with the platysma muscle.

On the upper side, the preparation of the SMAS flap consists of a horizontal incision 1 cm below the zygomatic arch reaching the malar eminence, and a vertical incision in the preauricular region along the posterior portion of the platysma muscle that continues until finding a point placed 5-6 cm from the bottom of the mandibula .

The dissection is done very carefully to avoid any damage to the branches of the facial nerve. Once the flap is established it is possible to proceed with superficial parotidectomy. After the procedure is completed, reconstruction was accomplished by suturing the SMAS on the zygomatic periosteum and parotid-masseteric fascia (Fig. 2).

Results

A total of 123 patients were enrolled, 56 women and 67 men (average age 51 years); 98 adenomas and 25 cystad enolynphomas were diagnosed on the histopathological report. Superficial parotidectomy was performed in all the cases reported. We performed reconstruction with SMAS flap in 64 patients. In Group 1, we found 6 cases of transient paralysis of the facial nerve, 1 case of facial paralysis, 12 Frey's syndrome, 8 skin depressions, 8 salivary fistulas, 2 wound infections and 5 haematoma. In Group 2, there were no cases of Frey's syndrome. We encountered 2 cases of transient paralysis of the facial nerve, 2 cases of salivary fistula, 2 cases of skin depression, 1 wound infection, no facial paralysis and 3 haematomas. We also evaluated the satisfaction in patients with and without SMAS flaps reconstruction; 53 of 64 patients operated with SMAS flap (Group 2) achieved an excellent result, and 11 patients had a good result. In patients without SMAS flap reconstruction (Group 1), the degree of satisfaction was much more variable; 15 patients reported a poor result, 18 patients an excellent result and 26 patients a good result. Table I shows outcome results of χ2 test comparing the first and the second group: except for wound infections and haematomas, which have a similar incidence, the complication rate was higher in Group 1 patients. Furthermore, the rate occurrence of Frey's syndrome was 20.33% in Group 1 and 0% in Group 2 [P<0.05]. Transient facial nerve weakness was significantly more frequent in Group 1 (10.16%) than in Group 2 (3.125%) [P<0.05]. The presence of fistulas, dip skin and accessory spinal nerve injury was significantly more frequent in Group 1 [P<0.05].

Table I.

Results of χ2 test of group 1 vs group 2.

	Group 1	Group 2	p value
n	59	64
Frey's syndrome	12 (20.33%)	0 (0.0%)	< 0.05
Transient facial nerve weakness	6 (10.16%)	2 (3.125%)	< 0.05
Fistula	8 (13.55%)	2 (3.125%)	< 0.05
Dip skin	8 (13.55%)	2 (3.125%)	< 0.05
Wound infection	2 (3.38%)	1 (1.56%)	> 0.05
Haematoma	5 (8.47%)	3 (4.68%)	> 0.05
Facial paralysis	1 (1.69%)	0 (0.00%)	> 0.05

Discussion

In 1903 for first Gutierrez described the parotidectomy approach for benign parotid neoplasm removal. Then Patey , and Patey and Thackeray described the concept of superficial parotidectomy for benign tumours of the parotid gland. This technique is used when faced with tumours greater than 4 cm in diameter, located in the deep portion of the gland and in recurrences . Parotidectomy is used in these tumours because excision of the tumour would be incomplete using extracapsular dissection techniques. Foresta et al. , in a recent review and ensuing meta-analysis based on 123 studies over the last 65 years, compared the two techniques and found fewer complications and recurrences in the extracapsular dissection. They concluded that in patients with unilateral pleomorphic adenoma, located in the superficial lobe, sized less than 4 cm and with no clinical involvement of cranial nerve VII, extracapsular dissection represents a viable alternative option to superficial parotidectomy in terms of successful outcome, convenience and ease of performance. According to Foresta et al., in our study, we perform 123 superificial parotidectomy related to exeresis of disease recurrences, tumours located in the deep portion of the parotid gland or larger than 4 cm. Superficial parotidectomy, however, is not free from complications. We can include, for example, the presence of an unsightly scar especially in women and other functional complications such as Frey's syndrome, facial paralysis, haematoma and fistula. For this reason, the introduction of the face-lift by Appiani and Delfino in 1984 produces less skin scarring. This surgical approach alone, however, cannot eliminate the depression of the skin after the removal of a tumour. Actually, the removal of the tumour leaves a cavity which results in a facial asymmetry with unpleasant aesthetic outcome. Furthermore, the lack of interface between the muscle-aponeurotic residual parenchyma and skin predisposes to the onset of salivary fistula and Frey Syndrome.

Frey's syndrome or auriculotemporal nerve syndrome was described for the first time by Lucy Frey in 1923 and is characterised by the appearance of redness, pain, sweating and heat in the parotid region following gustatory stimulus. This is caused by an abnormal post-parotidectomy reinnervation of the auriculotemporal nerve that eventually causes improper innervation to the sweat glands of the skin. To prevent this type of syndrome, a barrier must be formed between the postganglionic parasympathetic nerve fibres and sweat glands of skin flap, thereby preventing this type of connection -. The percentage of this syndrome in the literature varies widely. This could be due to the fact that most of the time there is a late onset of this syndrome compared to the short-term post-operative follow-up reported. Bremerich, for example, analysed the occurrence of Frey's syndrome in 372 patients who had a benign tumour of the parotid gland removed. In this study, we can verify that while about 50% of Frey's syndrome developed within 12 months after surgery, approximately 20% patients developed it after 24 months . Precisely for this reason, we believe that our study, which has a mean follow up of 84 months, makes a valid contribution to the literature and achieves very good results regarding the occurrence of this syndrome. To remedy functional and aesthetic complications, various possible treatments are described, such as radiotherapy, oral medication and botulinum toxin or surgical techniques. If symptoms are of low intensity, however, they do not require any type of treatment -. The use of non-biological materials such as acellular dermis may decrease the incidence of Frey's syndrome, but greatly increases the incidence of salivary fistula . Some authors suggest the use of the temporoparietal fascia flap in case of surgical gaps larger than 3 cm, in spite of significant decreases in the rate of Frey's syndrome, and it can cause other types of functional complications such as paralysis of the facial nerve, haematoma and aesthetic complications such as alopecia and extension of the surgical scar in the temporal region. In addition, compared to other surgical flaps, the time of duration greatly increases -.

The SCM flap is another flap described in the literature that can lower the onset of the Frey's syndrome. It is easy to set up, but has a greater risk of complications such as spinal accessory nerve injury, neck pain and cranial haematoma -. In addition, Sanabria in a recent study found that it greatly lowers the onset of Frey's syndrome. Indeed, we are accustomed to using this type of technique only in the case of recurrences that require a second surgery.

Precisely for the type of complications described for other reconstructive techniques, we believe that the SMAS flap is effective for resurfacing the surgical cavity after parotid surgery. It may, in fact, prevent Frey's syndrome, fill the depression and preserve facial symmetry. The withdrawal of the SMAS flap is very simple because the initial surgical incision is followed, the flap from the parotid fascia is separated and prepared to rebuild the cavity . Certainly the use of the SMAS flap to improve post-parotidectomy defects is not new. The first to use this type of flap was reported by Rappaport and Allison who studied 112 patients and found only 2 cases of Frey's syndrome. The same flap was used by Casler et al. in 1991 who found no cases of of Frey's syndrome and by Bonanno and Casson in 1992 with excellent results. Cesteleyn et al., in 2002 , also showed that with the SMAS flap the timing of the recovery of the facial nerve decreases from 3 to 1.5 months. Honig in 2005 and Meningaud in 2006 continued to propose this type of post-parotidectomy flap. Curry et al. in two studies explained how the SMAS flap together with fat grafting can improve facial asymmetry and prevent Frey's syndrome. Wille-Bischofberger et al. in their study analysed the effectiveness of SMAS flap reconstruction compared to a group where the flap had not been used. The same flap was used by Zhao et al. and by Arden et al. with excellent results. The effectiveness of this type of flap has also been reported by Durgut et al. and by Barbera et al. in two very interesting publications. Both explain that the use of the SMAS flap prevents Frey's syndrome and provides very satisfactory aesthetic results. The use of this flap, however, is not recommended in the case of malignant tumours, because the SMAS flap extends into the superficial capsular layers of the parotid gland, and in patients with thin subcutaneous tissue . The use of reconstruction technique in our study was associated with a substantial decrease in Frey's syndrome in Group 1 patients (20.33%) compared to Group 2 (0.00%) and in deep skin in Group 1 patients (13.55%) compared to Group 2 (.125%).

Conclusions

In conclusion, the results of this study reveal that there was a statistically significant difference in functional and aesthetic post-parotidectomy complications between Group 1 and Group 2. The onset of Frey's syndrome decreased in the case of reconstruction with SMAS flap. Moreover, thanks to a specific questionnaire on patient satisfaction, in aesthetic terms reconstruction with SMAS flap gave a higher level of satisfaction.