Michelle S Horner1, Maureen Reynolds2, Betty Braxter3, Levent Kirisci2, Ralph E Tarter2. 1. University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA; Center for Education and Drug Abuse Research (CEDAR), Pittsburgh, PA, USA. 2. Center for Education and Drug Abuse Research (CEDAR), Pittsburgh, PA, USA; University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA. 3. Center for Education and Drug Abuse Research (CEDAR), Pittsburgh, PA, USA; University of Pittsburgh School of Nursing, Pittsburgh, PA, USA.
Abstract
OBJECTIVE: This prospective study determined whether temperament before two years of age predicts transmissible risk for substance use disorder (SUD) up to a decade later and SUD outcome in adulthood. METHOD: Boys between 10 and 12 years of age (N = 482) were tracked to age 22. The previously validated transmissible liability index (TLI) was administered at baseline, and temperament prior to two years of age was retrospectively rated. The Structured Clinical Interview for DSM-III-R (SCID) was administered to document presence/absence of SUD for parents at baseline and sons at age 22. RESULTS: Path analysis revealed that number of parents with SUD predicted severity of temperament disturbance in their sons which in turn predicted TLI score at age 10-12, presaging SUD. Temperament before age two did not predict SUD at age 22. The association between number of SUD parents and transmissible risk was mediated by severity of temperament disturbance. CONCLUSION: Temperament disturbance in early childhood, reflecting quality of behavioral and emotion regulation, comprise psychological antecedents of transmissible risk for SUD.
OBJECTIVE: This prospective study determined whether temperament before two years of age predicts transmissible risk for substance use disorder (SUD) up to a decade later and SUD outcome in adulthood. METHOD:Boys between 10 and 12 years of age (N = 482) were tracked to age 22. The previously validated transmissible liability index (TLI) was administered at baseline, and temperament prior to two years of age was retrospectively rated. The Structured Clinical Interview for DSM-III-R (SCID) was administered to document presence/absence of SUD for parents at baseline and sons at age 22. RESULTS: Path analysis revealed that number of parents with SUD predicted severity of temperament disturbance in their sons which in turn predicted TLI score at age 10-12, presaging SUD. Temperament before age two did not predict SUD at age 22. The association between number of SUD parents and transmissible risk was mediated by severity of temperament disturbance. CONCLUSION: Temperament disturbance in early childhood, reflecting quality of behavioral and emotion regulation, comprise psychological antecedents of transmissible risk for SUD.
Authors: Michael M Vanyukov; Levent Kirisci; Ralph E Tarter; Howard F Simkevitz; Galina P Kirillova; Brion S Maher; Duncan B Clark Journal: Neurosci Biobehav Rev Date: 2003-10 Impact factor: 8.989
Authors: Michael M Vanyukov; Ralph E Tarter; Levent Kirisci; Galina P Kirillova; Brion S Maher; Duncan B Clark Journal: Neurosci Biobehav Rev Date: 2003-10 Impact factor: 8.989
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