Jung Jae Park1, Chan Kyo Kim2, Byung Kwan Park1. 1. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 2. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Medical Device Management & Research, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Electronic address: chankyokim@skku.edu.
Abstract
PURPOSE: To evaluate the prognostic value of diffusion-weighted imaging (DWI) and positron emission tomography/computed tomography (PET/CT) for predicting disease progression after concurrent chemoradiotherapy (CCRT) in cervical cancer. MATERIALS AND METHODS: A total of 67 locally advanced cervical cancer patients who received CCRT underwent both DWI and PET/CT before and during (at 1month) treatment. The mean apparent diffusion coefficient (ADCmean) and maximum standardized uptake value (SUVmax) were measured on the tumor and the percentage changes between 2 time points (ΔADCmean and ΔSUVmax) were calculated. The ΔADCmean and ΔSUVmax were compared in terms of predicting disease progression after CCRT. RESULTS: During a mean follow-up of 2.7years, disease progression was identified in 16 patients (23.9%). The ΔADCmean and ΔSUVmax were significantly correlated (Spearman correlation coefficient, 0.38; P=0.002). For predicting disease progression, the integrated area under the curves of ΔADCmean (0.791) and ΔSUVmax (0.781) were not significantly different (P=0.88). On multivariate analysis, both ΔADCmean and ΔSUVmax were the independent predictors of disease progression (hazard ratio, 7.9 and 8.7; P, 0.001 and <0.001, respectively). CONCLUSION: The percentage changes of ADCmean and SUVmax during CCRT have a similar prognostic value for predicting disease progression after CCRT in cervical cancers.
PURPOSE: To evaluate the prognostic value of diffusion-weighted imaging (DWI) and positron emission tomography/computed tomography (PET/CT) for predicting disease progression after concurrent chemoradiotherapy (CCRT) in cervical cancer. MATERIALS AND METHODS: A total of 67 locally advanced cervical cancerpatients who received CCRT underwent both DWI and PET/CT before and during (at 1month) treatment. The mean apparent diffusion coefficient (ADCmean) and maximum standardized uptake value (SUVmax) were measured on the tumor and the percentage changes between 2 time points (ΔADCmean and ΔSUVmax) were calculated. The ΔADCmean and ΔSUVmax were compared in terms of predicting disease progression after CCRT. RESULTS: During a mean follow-up of 2.7years, disease progression was identified in 16 patients (23.9%). The ΔADCmean and ΔSUVmax were significantly correlated (Spearman correlation coefficient, 0.38; P=0.002). For predicting disease progression, the integrated area under the curves of ΔADCmean (0.791) and ΔSUVmax (0.781) were not significantly different (P=0.88). On multivariate analysis, both ΔADCmean and ΔSUVmax were the independent predictors of disease progression (hazard ratio, 7.9 and 8.7; P, 0.001 and <0.001, respectively). CONCLUSION: The percentage changes of ADCmean and SUVmax during CCRT have a similar prognostic value for predicting disease progression after CCRT in cervical cancers.
Authors: Matthew M Harkenrider; Merry Jennifer Markham; Don S Dizon; Anuja Jhingran; Ritu Salani; Ramy K Serour; Jean Lynn; Elise C Kohn Journal: J Natl Cancer Inst Date: 2020-11-01 Impact factor: 13.506