Literature DB >> 26900065

Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy.

Vineeta Tiwari1, Vinod Tiwari1, Shaoqiu He1, Tong Zhang1, Srinivasa N Raja1, Xinzhong Dong1, Yun Guan2.   

Abstract

The founding member of the Mas-related G-protein-coupled receptor (Mrgpr) family was discovered in 1986. Since then, many more members of this receptor family have been identified in multiple species, and their physiologic functions have been investigated widely. Because they are expressed exclusively in small-diameter primary sensory neurons, the roles of Mrgpr proteins in pain and itch have been best studied. This review will focus specifically on the current knowledge of their roles in pathological pain and the potential development of new pharmacotherapies targeted at some Mrgprs for the treatment of chronic pain. We will also discuss the limitations and future scope of this receptor family in pain treatment.

Entities:  

Keywords:  Dorsal root ganglion; Mas-related G-protein-coupled receptors; Mrgpr; Nerve injury; Pain

Mesh：

Substances：

Year:  2016        PMID： 26900065     DOI： 10.1007/978-94-017-7537-3_7

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  5 in total

1.  The cellular basis of protease-activated receptor 2-evoked mechanical and affective pain.

Authors:  Shayne N Hassler; Moeno Kume; Juliet M Mwirigi; Ayesha Ahmad; Stephanie Shiers; Andi Wangzhou; Pradipta R Ray; Serge N Belugin; Dhananjay K Naik; Michael D Burton; Josef Vagner; Scott Boitano; Armen N Akopian; Gregory Dussor; Theodore J Price
Journal:  JCI Insight       Date:  2020-06-04

Review 2.  Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22.

Authors:  Sadashiva S Karnik; Khuraijam Dhanachandra Singh; Kalyan Tirupula; Hamiyet Unal
Journal:  Br J Pharmacol       Date:  2017-03-09       Impact factor: 8.739

3.  The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging.

Authors:  Silvia Lo Vecchio; Hjalte Holm Andersen; Lars Arendt-Nielsen
Journal:  Exp Brain Res       Date:  2018-05-29       Impact factor: 1.972

4.  Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain.

Authors:  Javad Hami; Viola von Bohlen Und Halbach; Anja Tetzner; Thomas Walther; Oliver von Bohlen Und Halbach
Journal:  Heliyon       Date:  2021-11-18

Review 5.  The signaling pathway and polymorphisms of Mrgprs.

Authors:  Haley R Steele; Liang Han
Journal:  Neurosci Lett       Date:  2020-12-31       Impact factor: 3.046
  5 in total

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