| Literature DB >> 26898338 |
Yong-Jin Wu1, Yunhui Zhang2, Jeremy H Toyn2, John E Macor2, Lorin A Thompson2.
Abstract
This Letter describes an efficient ring-closing metathesis approach to 2-chloro-4-amino-pyrimido[4,5-c]azepines and 2-chloro-4-amino-pyrimido[4,5-c]oxepines. These chlorides were applied to the synthesis of several potent γ-secretase modulators (GSMs).Entities:
Keywords: 2-Chloro-pyrimido[4,5-c]azepin-4-amine; 2-Chloro-pyrimido[4,5-c]oxepin-4-amine; Ring-closing metathesis (RCM); γ-Secretase modulator (GSM)
Mesh：
Substances：
Year: 2016 PMID： 26898338 DOI： 10.1016/j.bmcl.2016.02.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823