| Literature DB >> 26897357 |
Rui Zhang1,2, Wan Yu3, Guanyu Liang4, Zhanjun Jia1, Zhengxin Chen2, Lin Zhao2, Yongsheng Yuan5, Xiaobin Zhou6, Daqian Li7, Shuying Shen8, Ning Liu2,9, Aihua Zhang4, Huibo Wang10,11, Gang Wang12.
Abstract
Glioblastoma (GBM) is the most common malignant brain tumor with poor prognosis and limited treatment options. Tumor suppressor candidate 1 (TUSC1) was recently identified as a potential tumor suppressor in human cancers. However, the expression and potential function of TUSC1 in GBM remain unclear. Herein, we report that TUSC1 is significantly decreased in GBM tissues and cell lines. Patients with high levels of TUSC1 displayed a significant better survival compared with those with low levels of TUSC1. Functional experiments demonstrated that exogenous expression of TUSC1 inhibited GBM cell proliferation and induced G1 phase arrest by down-regulating CDK4. Moreover, overexpression of TUSC1 retarded tumor growth in vivo. Together, our findings revealed that TUSC1 might be a crucial tumor suppressor gene and a novel therapeutic target for GBM.Entities:
Keywords: Glioblastoma; Proliferation; TUSC1; Tumor suppressor
Mesh：
Substances：
Year: 2016 PMID： 26897357 DOI： 10.1007/s10571-016-0339-2
Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046