Literature DB >> 26894651

A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation.

Lucie Pouché1,2,3, Matthias Koitka1,2, Jana Stojanova1,2,4, Jean-Baptiste Woillard1,2,3, Caroline Monchaud1,3, Claire Villeneuve1,2,3, Marie Essig1,2,5, Julie Abraham6, Yannick Le Meur7, Jean-Phillippe Rerolle5, Nassim Kamar8,9,10, Lionel Rostaing8,9,10, Pierre Merville11, Peggy Gandia12, Stephane Bouchet13, Britt-Sabina Petersen14, Pierre Marquet1,2,3, Nicolas Picard1,2,3.   

Abstract

AIM: To investigate the potential influence of variants in genes involved in the calcineurin pathway on the efficacy and toxicity of calcineurin inhibitors in renal transplantation. MATERIALS &
METHODS: Twenty-three polymorphisms in thirteen genes were tested in 381 renal transplant recipients receiving ciclosporin (n = 221) or tacrolimus (n = 160) and mycophenolate mofetil. Data were collected prospectively over the first year post-transplantation.
RESULTS: Multivariate survival analyses revealed no genetic associations with biopsy proven acute graft rejection and serious infections. Donor-recipient Cytomegalovirus mismatch was the only variable associated with serious infection.
CONCLUSION: This large exploratory study casts doubts on the potential interest of genetic biomarkers related to CNI pharmacodynamics but associations with other phenotypes in transplantation deserve further studies.

Entities:  

Keywords:  acute rejection; calcineurin; ciclosporin; genetic polymorphism; kidney transplantation; opportunistic infections; pharmacogenetics; tacrolimus

Mesh：

Substances：

Year:  2016        PMID： 26894651     DOI： 10.2217/pgs.15.181

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.533


  4 in total

Review 1.  Pharmacogenetics of posttransplant diabetes mellitus.

Authors:  P Lancia; T Adam de Beaumais; E Jacqz-Aigrain
Journal:  Pharmacogenomics J       Date:  2017-03-28       Impact factor: 3.550

2.  CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant.

Authors:  Stefano Turolo; Alberto Edefonti; Luciana Ghio; Sara Testa; William Morello; Giovanni Montini
Journal:  BMC Pediatr       Date:  2020-05-25       Impact factor: 2.125

3.  Association of the PPP3CA c.249G>A variant with clinical outcomes of tacrolimus-based therapy in kidney transplant recipients.

Authors:  Patricia C Salgado; Fabiana Dv Genvigir; Claudia R Felipe; Helio Tedesco-Silva; Jose O Medina-Pestana; Sonia Q Doi; Mario H Hirata; Rosario Dc Hirata
Journal:  Pharmgenomics Pers Med       Date:  2017-03-31

4.  Polymorphisms in mTOR and Calcineurin Signaling Pathways Are Associated With Long-Term Clinical Outcomes in Kidney Transplant Recipients.

Authors:  Antony Brayan Campos-Salazar; Fabiana Dalla Vecchia Genvigir; Claudia Rosso Felipe; Helio Tedesco-Silva; José Medina-Pestana; Gabriela Vieira Monteiro; Rodrigo de Gouveia Basso; Alvaro Cerda; Mario Hiroyuki Hirata; Rosario Dominguez Crespo Hirata
Journal:  Front Pharmacol       Date:  2018-11-14       Impact factor: 5.810
  4 in total

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