Vinod Wali1, Vishal V Wali2. 1. Associate Professor, Department of Biochemistry, Smt Kashibai Navale Medical College & General Hospital , Narhe, Pune, India . 2. Assistant Professor, Department of Dermatology, M R Medical College , Kalaburgi, India .
Abstract
INTRODCTION: Acrochordon or fibroepithelial polyp, commonly known as Skin tags (STs) are one of the most common benign skin condition, consisting of skin projecting from the surrounding skin, usually occurring on the eyelids, neck and axillae. Studies have found an association of STs with conditions such as obesity, diabetes mellitus and atherogenic lipid profile. Abdominal obesity and the consequent insulin resistance are said be important contributing factors for diabetes, dyslipidaemia and cardiovascular disease. AIM: To highlight the association of lipid profile, BMI, glucose, HbA1c and leptin levels in patients with STs. MATERIALS AND METHODS: This was a case control study conducted at tertiary care hospital in South India from April 2013 to May 2014. The cases were chosen those who are having minimum of 3 STs attending the dermatology clinic. A total of 171 patients were screened, out of which 126 satisfied the criteria for inclusion and were included in the final analysis. The significance of the difference between the groups was assessed by Student t-test (two tailed, independent) to find the significance on continuous scale between two groups on metric parameters, between cases and controls and p-value of <0.05 were considered as statistically significant. RESULTS: Maximum cases were in males and in age group of 41-50 years. There was significant association between STs and triglycerides, low density lipoprotein, very low density lipoprotein cholesterol and leptin levels. Other parameters were also altered but no statistically significant difference was seen. CONCLUSION: STs are associated with change in markers of obesity and dyslipidaemia. Patients with STs need suitable interventions like weight reduction, smoking cessation, change in dietary habits. STs may also play a role in early diagnosis of metabolic syndrome.
INTRODCTION: Acrochordon or fibroepithelial polyp, commonly known as Skin tags (STs) are one of the most common benign skin condition, consisting of skin projecting from the surrounding skin, usually occurring on the eyelids, neck and axillae. Studies have found an association of STs with conditions such as obesity, diabetes mellitus and atherogenic lipid profile. Abdominal obesity and the consequent insulin resistance are said be important contributing factors for diabetes, dyslipidaemia and cardiovascular disease. AIM: To highlight the association of lipid profile, BMI, glucose, HbA1c and leptin levels in patients with STs. MATERIALS AND METHODS: This was a case control study conducted at tertiary care hospital in South India from April 2013 to May 2014. The cases were chosen those who are having minimum of 3 STs attending the dermatology clinic. A total of 171 patients were screened, out of which 126 satisfied the criteria for inclusion and were included in the final analysis. The significance of the difference between the groups was assessed by Student t-test (two tailed, independent) to find the significance on continuous scale between two groups on metric parameters, between cases and controls and p-value of <0.05 were considered as statistically significant. RESULTS: Maximum cases were in males and in age group of 41-50 years. There was significant association between STs and triglycerides, low density lipoprotein, very low density lipoprotein cholesterol and leptin levels. Other parameters were also altered but no statistically significant difference was seen. CONCLUSION: STs are associated with change in markers of obesity and dyslipidaemia. Patients with STs need suitable interventions like weight reduction, smoking cessation, change in dietary habits. STs may also play a role in early diagnosis of metabolic syndrome.
Authors: P Bhargava; S K Mathur; D K Mathur; S Malpani; S Goel; U S Agarwal; R K Bhargava Journal: Indian J Dermatol Venereol Leprol Date: 1996 Jul-Aug Impact factor: 2.545
Authors: Miguel Otero; Rocío Lago; Francisca Lago; Felipe F Casanueva; Carlos Dieguez; Juan Jesús Gómez-Reino; Oreste Gualillo Journal: FEBS Lett Date: 2005-01-17 Impact factor: 4.124