Literature DB >> 26892851

Changes in extra-striatal functional connectivity in patients with schizophrenia in a psychotic episode.

Henning Peters1, Valentin Riedl1, Andrei Manoliu1, Martin Scherr1, Dirk Schwerthöffer1, Claus Zimmer1, Hans Förstl1, Josef Bäuml1, Christian Sorg1, Kathrin Koch2.   

Abstract

BACKGROUND: In patients with schizophrenia in a psychotic episode, intra-striatal intrinsic connectivity is increased in the putamen but not ventral striatum. Furthermore, multimodal changes have been observed in the anterior insula that interact extensively with the putamen. AIMS: We hypothesised that during psychosis, putamen extra-striatal functional connectivity is altered with both the anterior insula and areas normally connected with the ventral striatum (i.e. altered functional connectivity distinctiveness of putamen and ventral striatum).
METHOD: We acquired resting-state functional magnetic resonance images from 21 patients with schizophrenia in a psychotic episode and 42 controls.
RESULTS: Patients had decreased functional connectivity: the putamen with right anterior insula and dorsal prefrontal cortex, the ventral striatum with left anterior insula. Decreased functional connectivity between putamen and right anterior insula was specifically associated with patients' hallucinations. Functional connectivity distinctiveness was impaired only for the putamen.
CONCLUSIONS: Results indicate aberrant extra-striatal connectivity during psychosis and a relationship between reduced putamen-right anterior insula connectivity and hallucinations. Data suggest that altered intrinsic connectivity links striatal and insular pathophysiology in psychosis. © The Royal College of Psychiatrists 2017.

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Year:  2016        PMID: 26892851     DOI: 10.1192/bjp.bp.114.151928

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  9 in total

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9.  Differential Resting-State Connectivity Patterns of the Right Anterior and Posterior Dorsolateral Prefrontal Cortices (DLPFC) in Schizophrenia.

Authors:  Natalia Chechko; Edna C Cieslik; Veronika I Müller; Thomas Nickl-Jockschat; Birgit Derntl; Lydia Kogler; André Aleman; Renaud Jardri; Iris E Sommer; Oliver Gruber; Simon B Eickhoff
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  9 in total

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