Rebecca Guy1, Lourda Geoghegan2, Maggie Heginbothom3, Robin Howe4, Berit Muller-Pebody1, Jacqui S Reilly5, Julie Wilson5, Camilla Wiuff5, Tim Wyatt2, Alan P Johnson6. 1. Centre for Infectious Disease Surveillance and Control, National Infection Service, Public Health England, London NW9 5EQ, UK. 2. Health Protection Service, Public Health Agency, Belfast BT2 8BS, UK. 3. Antimicrobial Resistance Programme, Public Health Wales, Cardiff CF10 3NW, UK. 4. Department of Microbiology, Public Health Wales, Cardiff CF14 4XW, UK. 5. Health Protection Scotland, NHS National Services Scotland, Glasgow G2 6QE, UK. 6. Centre for Infectious Disease Surveillance and Control, National Infection Service, Public Health England, London NW9 5EQ, UK alan.johnson@phe.gov.uk.
Abstract
OBJECTIVES: To monitor and compare trends in the non-susceptibility of bloodstream isolates of pathogens to key antibiotics in the constituent countries of the UK between 2010 and 2014. METHODS: Routinely generated antibiotic susceptibility test results for bloodstream isolates of Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas spp., Streptococcus pneumoniae and Staphylococcus aureus were collected from hospital microbiology laboratories in each country. RESULTS: With the exception of a decrease in the proportion of S. aureus that were MRSA, non-susceptibility to key antibiotics among the pathogens studied remained largely unchanged over the 5 year study period, with any increases in non-susceptibility being small. Although some intercountry variation in the proportions of non-susceptible isolates was seen, apart from MRSA, the differences were generally small (<5%) and fluctuated from year to year, with no country showing consistently higher or lower rates of resistance. CONCLUSIONS: Collaboration between the constituent countries of the UK allows an integrated approach to nationwide surveillance of antibiotic resistance.
OBJECTIVES: To monitor and compare trends in the non-susceptibility of bloodstream isolates of pathogens to key antibiotics in the constituent countries of the UK between 2010 and 2014. METHODS: Routinely generated antibiotic susceptibility test results for bloodstream isolates of Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas spp., Streptococcus pneumoniae and Staphylococcus aureus were collected from hospital microbiology laboratories in each country. RESULTS: With the exception of a decrease in the proportion of S. aureus that were MRSA, non-susceptibility to key antibiotics among the pathogens studied remained largely unchanged over the 5 year study period, with any increases in non-susceptibility being small. Although some intercountry variation in the proportions of non-susceptible isolates was seen, apart from MRSA, the differences were generally small (<5%) and fluctuated from year to year, with no country showing consistently higher or lower rates of resistance. CONCLUSIONS: Collaboration between the constituent countries of the UK allows an integrated approach to nationwide surveillance of antibiotic resistance.
Authors: M Opatowski; P Tuppin; K Cosker; M Touat; G De Lagasnerie; D Guillemot; J Salomon; C Brun-Buisson; L Watier Journal: Epidemiol Infect Date: 2019-01 Impact factor: 2.451