Enas Samir Nabih1, Nevine Gamal Andrawes2. 1. Department of Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt. enassamer@hotmail.com. 2. Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
BACKGROUND: miRNA-181a has been implicated in autoimmunity and apoptosis. Therefore, this study was conducted to explore its possible role in pancreatic beta-cells dysfunction. METHODS: miRNA-181a expression was evaluated by real-time PCR in serum of 40 type 1 diabetic children and adolescents and 40 age- and gender-matched healthy controls. RESULTS: miRNA-181a expression was significantly higher in diabetic children and adolescents and it was negatively correlated to fasting C-peptide and SMAD7 levels. CONCLUSION: miRNA-181a appears to play a potential role in pancreatic beta-cells dysfunction via SMAD7.
BACKGROUND: miRNA-181a has been implicated in autoimmunity and apoptosis. Therefore, this study was conducted to explore its possible role in pancreatic beta-cells dysfunction. METHODS: miRNA-181a expression was evaluated by real-time PCR in serum of 40 type 1 diabeticchildren and adolescents and 40 age- and gender-matched healthy controls. RESULTS: miRNA-181a expression was significantly higher in diabeticchildren and adolescents and it was negatively correlated to fasting C-peptide and SMAD7 levels. CONCLUSION: miRNA-181a appears to play a potential role in pancreatic beta-cells dysfunction via SMAD7.
Authors: Hao Zhu; Ng Shyh-Chang; Ayellet V Segrè; Gen Shinoda; Samar P Shah; William S Einhorn; Ayumu Takeuchi; Jesse M Engreitz; John P Hagan; Michael G Kharas; Achia Urbach; James E Thornton; Robinson Triboulet; Richard I Gregory; David Altshuler; George Q Daley Journal: Cell Date: 2011-09-30 Impact factor: 41.582