Sokunthea Peou1, Brittany Milliard-Hasting2, Sachin A Shah3. 1. Department of Pharmacy, David Grant Medical Center, Travis Air Force Base, Fairfield, CA, USA. 2. Clinical Investigations Facility, David Grant Medical Center, Travis Air Force Base, USA. 3. Department of Pharmacy, David Grant Medical Center, Travis Air Force Base, Fairfield, CA, USA; Department of Pharmacy Practice, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA, USA. Electronic address: sshah@pacific.edu.
Abstract
BACKGROUND: Optimizing plasma lipoproteins is the primary goal of pharmacotherapy and diet interventions in people at risk for cardiovascular diseases. Avocados offer a rich source of monounsaturated fat and may pose beneficial effects on the lipid profile. OBJECTIVE: We aimed to perform a meta-analysis of randomized clinical trials assessing the impact of avocados on TC, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and/or triglycerides (TG). METHODS: We searched PUBMED, Cumulative Index to Nursing and Allied Health Literature, Index to Nursing and Allied Health Literature, and the Cochrane Database of Systemic Reviews from their inception to February 2015. The weighted mean difference from baseline was calculated for all endpoints. Subgroup analyses were performed to assess heterogeneity, and funnel plots inspected to assess publication bias. RESULTS: Ten unique studies (n = 229) were included. Avocado consumption significantly reduced TC, LDL-C, and TG by -18.80 mg/dL (95% confidence interval [CI], -24.56 to -13.05; I(2), 46.9%), -16.50 mg/dL (95% CI, -22.91 to -10.10; I(2), 72.5%), -27.20 mg/dL (95% CI, -44.41 to -9.99; I(2), 91.1%) respectively. High-density lipoprotein cholesterol decreased nonsignificantly by -0.18 mg/dL (95% CI, -3.23 to 2.88; I(2), 84.8%). CONCLUSION: Avocado-substituted diets significantly decrease TC, LDL-C, and TG levels. Substituting dietary fats with avocados versus adding to the free diet should be the primary recommendation strategy. Larger trials looking at the impact of avocados on major adverse cardiovascular events are warranted.
BACKGROUND: Optimizing plasma lipoproteins is the primary goal of pharmacotherapy and diet interventions in people at risk for cardiovascular diseases. Avocados offer a rich source of monounsaturated fat and may pose beneficial effects on the lipid profile. OBJECTIVE: We aimed to perform a meta-analysis of randomized clinical trials assessing the impact of avocados on TC, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and/or triglycerides (TG). METHODS: We searched PUBMED, Cumulative Index to Nursing and Allied Health Literature, Index to Nursing and Allied Health Literature, and the Cochrane Database of Systemic Reviews from their inception to February 2015. The weighted mean difference from baseline was calculated for all endpoints. Subgroup analyses were performed to assess heterogeneity, and funnel plots inspected to assess publication bias. RESULTS: Ten unique studies (n = 229) were included. Avocado consumption significantly reduced TC, LDL-C, and TG by -18.80 mg/dL (95% confidence interval [CI], -24.56 to -13.05; I(2), 46.9%), -16.50 mg/dL (95% CI, -22.91 to -10.10; I(2), 72.5%), -27.20 mg/dL (95% CI, -44.41 to -9.99; I(2), 91.1%) respectively. High-density lipoprotein cholesterol decreased nonsignificantly by -0.18 mg/dL (95% CI, -3.23 to 2.88; I(2), 84.8%). CONCLUSION:Avocado-substituted diets significantly decrease TC, LDL-C, and TG levels. Substituting dietary fats with avocados versus adding to the free diet should be the primary recommendation strategy. Larger trials looking at the impact of avocados on major adverse cardiovascular events are warranted.
Authors: Lorena S Pacheco; Yanping Li; Eric B Rimm; JoAnn E Manson; Qi Sun; Kathryn Rexrode; Frank B Hu; Marta Guasch-Ferré Journal: J Am Heart Assoc Date: 2022-03-30 Impact factor: 6.106
Authors: Lorena S Pacheco; Ryan D Bradley; Julie O Denenberg; Cheryl A M Anderson; Matthew A Allison Journal: Nutrients Date: 2021-11-11 Impact factor: 6.706
Authors: Verónica V Olavarría; Paola Campodónico; Valeska Vollrath; Paula von Geldern; Carolina Velásquez; Patricia Pavez; Barbara Valente; Pamela Donoso; Alexandra Ginesta; Gabriel Cavada; Enrico Mazzon; Víctor Navia; Matías Guzmán; Pablo Brinck; Pablo M Lavados Journal: Medicine (Baltimore) Date: 2021-06-18 Impact factor: 1.889