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Literature DB >> 26891193

The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases.

Abstract

The Na/K-ATPase has been extensively studied, but it is only recently that its role as a scaffolding and signaling protein has been identified. It has been identified that cardiotonic steroids (CTS) such as digitalis mediate signal transduction through the Na/K-ATPase in a process found to result in the generation of reactive oxygen species (ROS). As these ROS also appear capable of initiating this signal cascade, a feed forward amplification process has been postulated and subsequently implicated in some disease pathways including uremic cardiomyopathy.

Entities: Chemical Disease Gene Species

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Year: 2016 PMID： 26891193 PMCID： PMC5161351 DOI： 10.1016/j.coph.2016.01.009

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

66 in total

1. Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells.

Authors: Jiang Liu; Sankaridrug M Periyasamy; William Gunning; Olga V Fedorova; Alexei Y Bagrov; Deepak Malhotra; Zijian Xie; Joseph I Shapiro
Journal: Kidney Int Date: 2002-12 Impact factor: 10.612

2. Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog.

Authors: H E DE WARDENER; I H MILLS; W F CLAPHAM; C J HAYTER
Journal: Clin Sci Date: 1961-10 Impact factor: 6.124

3. Identification and characterization of a ouabain-like compound from human plasma.

Authors: J M Hamlyn; M P Blaustein; S Bova; D W DuCharme; D W Harris; F Mandel; W R Mathews; J H Ludens
Journal: Proc Natl Acad Sci U S A Date: 1991-07-15 Impact factor: 11.205

4. Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state.

Authors: Maria Nyblom; Hanne Poulsen; Pontus Gourdon; Linda Reinhard; Magnus Andersson; Erik Lindahl; Natalya Fedosova; Poul Nissen
Journal: Science Date: 2013-09-19 Impact factor: 47.728

5. Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure.

Authors: Steven T Haller; David J Kennedy; Amjad Shidyak; George V Budny; Deepak Malhotra; Olga V Fedorova; Joseph I Shapiro; Alexei Y Bagrov
Journal: Am J Hypertens Date: 2012-03-01 Impact factor: 2.689

6. Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase.

Authors: M Haas; A Askari; Z Xie
Journal: J Biol Chem Date: 2000-09-08 Impact factor: 5.157

Review 7. Atrial natriuretic factor.

Authors: V M Buckalew; M Morris; R W Hamilton
Journal: Adv Intern Med Date: 1987

Review 8. The pathophysiology of renal insufficiency. On the functional transformations in the residual nephrons with advancing disease.

Authors: N S Bricker; S Klahr; H Lubowitz; E Slatopolsky
Journal: Pediatr Clin North Am Date: 1971-05 Impact factor: 3.278

9. Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin.

Authors: Jiang Tian; Amjad Shidyak; Sankaridrug M Periyasamy; Steven Haller; Mohamed Taleb; Nasser El-Okdi; Jihad Elkareh; Shalini Gupta; Sabry Gohara; Olga V Fedorova; Christopher J Cooper; Zijian Xie; Deepak Malhotra; Alexei Y Bagrov; Joseph I Shapiro
Journal: Hypertension Date: 2009-11-02 Impact factor: 10.190

10. NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-activated signal transduction in cultured cells.

Authors: Zhichuan Li; Ting Cai; Jiang Tian; Joe X Xie; Xiaochen Zhao; Lijun Liu; Joseph I Shapiro; Zijian Xie
Journal: J Biol Chem Date: 2009-06-08 Impact factor: 5.157

19 in total

Review 1. Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress.

Authors: Jiang Liu; Megan N Lilly; Joseph I Shapiro
Journal: Curr Pharm Des Date: 2018 Impact factor: 3.116

2. Smooth muscle Ca²⁺ sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation.

Authors: Christian Staehr; Lise Hangaard; Elena V Bouzinova; Sukhan Kim; Rajkumar Rajanathan; Peter Boegh Jessen; Nathan Luque; Zijian Xie; Karin Lykke-Hartmann; Shaun L Sandow; Christian Aalkjaer; Vladimir V Matchkov
Journal: J Cereb Blood Flow Metab Date: 2018-03-07 Impact factor: 6.200

Review 3. Role of Na⁺/K⁺-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology.

Authors: Mengyuan Zhu; Haijian Sun; Lei Cao; Zhiyuan Wu; Bin Leng; Jinsong Bian
Journal: J Mol Med (Berl) Date: 2021-11-27 Impact factor: 4.599

4. Bardoxolone methyl (CDDO-Me or RTA402) induces cell cycle arrest, apoptosis and autophagy via PI3K/Akt/mTOR and p38 MAPK/Erk1/2 signaling pathways in K562 cells.

Authors: Xin-Yu Wang; Xue-Hong Zhang; Li Peng; Zheng Liu; Yin-Xue Yang; Zhi-Xu He; Hong-Wan Dang; Shu-Feng Zhou
Journal: Am J Transl Res Date: 2017-10-15 Impact factor: 4.060

5. Low to Normal Plasma Levels of Marinobufagenin 24 Hours or More after an Ischemic Stroke: A Pilot Study.

Authors: Estela S Estapé; Lorena González-Sepúlveda; Wen Wei; Ingrid Rodríguez-Rivera; Ivette Torres-Negrón
Journal: Int Arch Transl Med Date: 2018-09-06

6. 21-Benzylidene digoxin decreases proliferation by inhibiting the EGFR/ERK signaling pathway and induces apoptosis in HeLa cells.

Authors: Marco Túlio C Pessôa; Jéssica M M Valadares; Sayonarah C Rocha; Simone C Silva; Jeff P McDermott; Gladis Sánchez; Fernando P Varotti; Cristóforo Scavone; Rosy I M A Ribeiro; José A F P Villar; Gustavo Blanco; Leandro A Barbosa
Journal: Steroids Date: 2019-12-06 Impact factor: 2.668

Review 10. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease.

Authors: David E Bartlett; Richard B Miller; Scott Thiesfeldt; Hari Vishal Lakhani; Joseph I Shapiro; Komal Sodhi
Journal: Int J Mol Sci Date: 2018-07-23 Impact factor: 5.923

The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases.

1. Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells.

2. Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog.

3. Identification and characterization of a ouabain-like compound from human plasma.

4. Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state.

5. Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure.

6. Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase.

Review 7. Atrial natriuretic factor.

Review 8. The pathophysiology of renal insufficiency. On the functional transformations in the residual nephrons with advancing disease.

9. Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin.

10. NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-activated signal transduction in cultured cells.

Review 1. Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress.

2. Smooth muscle Ca²⁺ sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation.

Review 3. Role of Na⁺/K⁺-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology.

4. Bardoxolone methyl (CDDO-Me or RTA402) induces cell cycle arrest, apoptosis and autophagy via PI3K/Akt/mTOR and p38 MAPK/Erk1/2 signaling pathways in K562 cells.

5. Low to Normal Plasma Levels of Marinobufagenin 24 Hours or More after an Ischemic Stroke: A Pilot Study.

6. 21-Benzylidene digoxin decreases proliferation by inhibiting the EGFR/ERK signaling pathway and induces apoptosis in HeLa cells.

7. Kappaphycus alvarezii as a Food Supplement Prevents Diet-Induced Metabolic Syndrome in Rats.

8. Spin Trapping: A Review for the Study of Obesity Related Oxidative Stress and Na⁺/K⁺-ATPase.

Review 9. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease.

Review 10. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease.

Review 7. Atrial natriuretic factor.

Review 8. The pathophysiology of renal insufficiency. On the functional transformations in the residual nephrons with advancing disease.

Review 1. Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress.

Review 3. Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology.

Review 9. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease.

Review 10. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease.

Review 3. Role of Na⁺/K⁺-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology.