| Literature DB >> 26891081 |
Subhamoy Das1, Anthony J Monteforte1, Gunjan Singh1, Marjan Majid1, Michael B Sherman2, Andrew K Dunn1, Aaron B Baker1,3,4,5.
Abstract
Delivering syndecan-4 with FGF-2 improves the effectiveness of FGF-2 therapy for ischemia in the diabetic disease state. The syndecan-4 proteoliposomes significantly enhance in vitro tubule formation as well as blood perfusion and vessel density in the ischemic hind limbs of diseased ob/ob mice. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype.Entities:
Keywords: fibroblast growth factor-2 (FGF-2); ischemia; peripheral vascular diseases; syndecan-4; therapeutic angiogenesis
Mesh:
Substances:
Year: 2016 PMID: 26891081 PMCID: PMC4864113 DOI: 10.1002/adhm.201500993
Source DB: PubMed Journal: Adv Healthc Mater ISSN: 2192-2640 Impact factor: 9.933