Literature DB >> 26891081

Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes.

Subhamoy Das1, Anthony J Monteforte1, Gunjan Singh1, Marjan Majid1, Michael B Sherman2, Andrew K Dunn1, Aaron B Baker1,3,4,5.   

Abstract

Delivering syndecan-4 with FGF-2 improves the effectiveness of FGF-2 therapy for ischemia in the diabetic disease state. The syndecan-4 proteoliposomes significantly enhance in vitro tubule formation as well as blood perfusion and vessel density in the ischemic hind limbs of diseased ob/ob mice. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  fibroblast growth factor-2 (FGF-2); ischemia; peripheral vascular diseases; syndecan-4; therapeutic angiogenesis

Mesh:

Substances:

Year:  2016        PMID: 26891081      PMCID: PMC4864113          DOI: 10.1002/adhm.201500993

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN: 2192-2640            Impact factor:   9.933


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